Notre Dame vs. Stanford Dunkel NCAA Football Picks, Predictions and Odds - Nov. 29

The No. 9 Notre Dame Fighting Irish (9-2) are massive, 31.5-point favorites on the road at Stanford Stadium against the Stanford Cardinal (4-7) on Saturday, November 29, 2025. Both teams feature solid rush defenses, with the Fighting Irish 12th against the run in the nation, and the Cardinal 25th defending the rushing attack.

Last time around, the Fighting Irish defeated the Syracuse Orange, with 70-7 being the final score.

Facing the California Golden Bears in their last contest, the Cardinal won 31-10.

Notre Dame vs. Stanford Predictions

For predictions on the upcoming contest between the Notre Dame Fighting Irish and Stanford Cardinal, computer-calculated against-the-spread, over/under, and score predictions are below, sourced from Dunkel Index.

• Pick ATS: Fighting Irish (- 31.5)
• Pick OU: Over (49.5)
  
• Prediction: Fighting Irish 45 - Cardinal 5

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Notre Dame vs. Stanford Moneylines

Snag a look below at the most up-to-date moneylines for the Fighting Irish-Cardinal matchup.

• Notre Dame Moneyline: -11111
• Stanford Moneyline: +2460

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Notre Dame Betting Insights

• Notre Dame has won eight of the 10 games it was listed as the moneyline favorite this season (80%).
• Notre Dame has not played a game this season with moneyline odds of -11111 or shorter.
• In eight of 11 games this season, the Fighting Irish and their opponents have combined to score more than 49.5 points.
• The Fighting Irish have an average point total of 55.9 in their outings this year, 6.4 more points than this matchup's over/under.
• The Cardinal are college football's 127th-highest scoring team this season compared to the ninth-ranked Fighting Irish.

Stanford Betting Insights

• Stanford has been an underdog in 10 games this season and won three (30%) of those contests.
• Stanford has not entered a game this season as a bigger underdog on the moneyline than the +2460 odds on them winning this game.
• Stanford has played four games this season that have had more than 49.5 combined points scored.
• Stanford has had an average of 48.8 points scored in their games so far this season, 0.7 points fewer than this game's over/under.

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Key Stats for Notre Dame vs. Stanford

• In their last three head-to-head matchups, Notre Dame has defeated Stanford two times.
• The last three times the Fighting Irish have matched up against the Cardinal, they have a 2-1 record against the spread. The scoring has gone over the point total on two occasions.
• The Fighting Irish have been clicking on all fronts this season, as they rank 20th-best in total offense (452.5 yards per game) and 21st-best in total defense (312.3 yards allowed per game).
• Notre Dame has been finding success on both sides of the ball, ranking fifth-best in scoring offense (41.4 points per game) and 13th-best in scoring defense (17.4 points allowed per game).
• The Cardinal's offense has been a bottom-25 unit in total offense this season, putting up 305.1 total yards per game, which ranks 11th-worst in the FBS. On the defensive side of the ball, they rank 95th with 397.6 total yards allowed per contest.
• Stanford has been sputtering on offense, ranking 12th-worst in the FBS with 18.7 points per game. It has been more effective defensively, giving up 27.4 points per contest (85th-ranked).