Twins vs. Giants Dunkel MLB Picks, Predictions and Prop Bets - Sept. 22

The San Francisco Giants host the Minnesota Twins at 9:45 p.m. ET on Tuesday. Taj Bradley (11-6, 3.81 ERA) will start for the Twins, who are 73-84 this season and fourth in the AL Central. Anthony Molina (3-1, 4.18 ERA) is the expected starter for the Giants, who are 65-92 and fourth in the NL West.

Despite being the away team the Twins are a moderate moneyline favorite (-135) over the Giants (+112). The total for the Twins-Giants game is set at 7.5.

Twins vs. Giants Odds, Game Time

• Game day: Tuesday, September 22, 2026
• Game time: 9:45 p.m. ET
• Location: San Francisco, California
• Stadium: Oracle Park
• Favorite: Twins (-135)
• Underdog: Giants (+112)
• Over/under: 7.5

How to Watch Twins vs. Giants

• TV Channel: NBCS-BA and MNNT
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Twins vs. Giants: Betting the Moneyline

• The Twins have put together a 32-27 record in games they were favored on the moneyline (winning 54.2% of those games).
• San Francisco has been pegged as an underdog in 107 games this year and has walked away with the win 40 times (37.4%) in those games.
• Minnesota has a record of 12-10, a 54.5% win rate, when favored by -135 or more by bookmakers this season.
• This year, the Giants have won 27 of 67 games when listed as at least +112 or worse on the moneyline.
• The Twins have a 57.4% chance to win this game based on the moneyline's implied probability.
• Sportsbooks have implied with the moneyline set for this matchup that the Giants have a 47.2% chance of pulling out a win.

Twins vs. Giants: Betting the Spread & Total

• The Twins have played in 157 games with a set over/under, and have combined with their opponents to go over the total 86 times (86-63-8).
• So far this season, San Francisco and its opponents have hit the over in 76 of its 156 games with a total.
• The Twins have an 83-74-0 record against the spread this season.
• The Giants have an against the spread mark of 78-78-0 in 156 games with a line this season.