Louisville vs. Indiana Dunkel Predictions & Vegas Odds - Dec. 6

The No. 6 Louisville Cardinals (7-1) visit the No. 22 Indiana Hoosiers (7-1) at Gainbridge Fieldhouse, beginning at 2:15 p.m. ET on Saturday, December 6, 2025. The Hoosiers are 4.5-point underdogs in the game. The point total is set at 158.5 for the matchup.

Louisville is coming off of an 89-80 loss to Arkansas in its last game on Wednesday. In the losing effort, Mikel Brown Jr. paced Louisville with 22 points. Indiana is coming off of a 73-64 loss to Minnesota in its most recent game on Wednesday. Tayton Conerway's team-leading 18 points paced Indiana in the losing effort.

Louisville vs. Indiana Odds and Game Time

• When: Saturday, December 6, 2025 at 2:15 p.m. ET
• Where: Gainbridge Fieldhouse in Indianapolis, Indiana
• Spread favorite: Louisville -4.5
• Moneyline favorite: Louisville -211
• Moneyline underdog: Indiana +174
• Over/Under: 158.5 points

How to watch Louisville vs. Indiana

• TV Channel: MyNetworkTV (KELO – Sioux Falls, SD)
• Live Stream: Fubo
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Louisville vs. Indiana

• Four of Louisville's games this season have gone over Saturday's over/under of 158.5 points.
• This season, just two Indiana games have finished with more combined points than Saturday's point total of 158.5.
• The over/under for the contest of 158.5 is 22.5 points fewer than the combined points per game averages for the Cardinals (94.6 points per game) and the Hoosiers (86.4 points per game).
• These two teams give up a combined 130.1 points per game, 28.4 points less than this contest's over/under.
• On average, Louisville has seen a 160.9-point over/under in its games this season, 2.4 more points than the over/under in this matchup.
• The over/under for this game is 8.4 points more than the average over/under in Indiana's games this season (150.1 points).

Betting the Spread: Louisville vs. Indiana

• Louisville is 5-3-0 against the spread this year.
• The Cardinals have been favored by 4.5 points or more seven times this season and are 5-2 ATS in those contests.
• In Indiana's eight games this year, it has five wins against the spread.
• At home this season, Indiana is 4-2 against the spread and 6-0 overall.
• As a 4.5-point underdog or more at home, Indiana is 4-2 ATS.

Betting the Moneyline: Louisville vs. Indiana

• Louisville has won six of the seven games it has played as the moneyline favorite this season.
• The Cardinals have been at least a -211 moneyline favorite six times this season and won each of those games.
• Louisville has a 67.8% chance to win this game based on the implied probability of the moneyline.
• Indiana has yet to play a game this season where it is listed as the moneyline underdog.
• This is the worst odds of a win that sportsbooks have given the Hoosiers this season with a +174 moneyline set for this game.
• The moneyline set for this matchup implies Indiana has a 36.5% chance of coming away with a victory in the contest.