Chiefs vs. Colts Week 12 Dunkel NFL Picks, Predictions and Odds

The Kansas City Chiefs (5-5) are considered favorites (-3.5) according to the oddsmakers ahead of their game against the Indianapolis Colts (8-2) on November 23, 2025, starting at 1 p.m. ET, airing on CBS. The game has an over/under of 50.5 points.

On offense, the Chiefs rank seventh in the NFL with 364.2 yards per game. Meanwhile, they rank seventh in total defense (296.8 yards allowed per contest). The Colts' offense has been leading the charge for the team, as they rank best in the NFL with 396.9 total yards per contest. In terms of defense, they are ceding 327.6 total yards per game, which ranks 19th.

Chiefs vs. Colts Odds and Game Time

• Date: Sunday, November 23, 2025
• Time: 1 p.m. ET
• City: Kansas City, Missouri
• Venue: GEHA Field at Arrowhead Stadium
• Total: 50.5 points
• Spread: Chiefs -3.5
• Moneyline: Chiefs (-175), Colts (+145)

How to watch Chiefs vs. Colts

• TV Channel: CBS (KBAK-Bakersfield, CA)
• Live Stream: Fubo

Betting the Over/Under: Chiefs vs. Colts

• The Chiefs and their opponents have scored a combined total of more than 50.5 points twice this season (over 10 games).
• A total of three out of 10 Kansas City games this season have gone over the point total.
• The Colts and their opponents have combined to score more than 50.5 points in six of 10 games this season.
• In 2025, six Indianapolis games have hit the over.
• The teams average 57.5 points per game combined, 7.0 more points than this game's total.
• Combined, these teams allow 38.7 points per game, 11.8 fewer points than this matchup's total.

Betting the Spread: Chiefs vs. Colts

• Kansas City has won five games against the spread this season, while failing to cover five times.
• Kansas City is 3-3 ATS this season when playing as at least 3.5-point favorites.
• The Colts are 6-4-0 ATS this season.
• Indianapolis has been an underdog by 3.5 points or more this season once, and failed to cover the spread.
• The Chiefs are 4-1 overall, and 4-1 against the spread, at home.
• At home, as 3.5-point favorites or greater, Kansas City is unbeaten ATS (2-0).
• The Colts are 2-2 overall with two wins against the spread away from home.
• Indianapolis is winless ATS (0-1) as 3.5-point underdogs or more away from home.

Betting the Moneyline: Chiefs vs. Colts

• Kansas City has won 50% of the games this season when it was the moneyline favorite (4-4).
• This season, the Colts have won two out of the three games in which they've been the underdog.
• Kansas City has a record of 3-3 when playing as a moneyline favorite with odds of -175 or shorter (50%).
• Indianapolis has played as an underdog of +145 or more once this season and lost that game.
• The Chiefs have a 63.6% chance to win this matchup based on the moneyline's implied probability.

Dunkel Prediction for Chiefs vs. Colts

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