Jaguars vs. Cardinals Week 12 Dunkel NFL Picks, Predictions and Odds

The Jacksonville Jaguars (6-4) are favored by 2.5 points against the Arizona Cardinals (3-7) on November 23, 2025, starting at 4:05 p.m. ET, airing on CBS. An over/under of 47.5 points has been established for the matchup.

The Jaguars are putting up 326.9 yards per game on offense this season (20th in NFL), and they are surrendering 323.6 yards per game (14th) on the defensive side of the ball. With 22.4 points per game on offense, the Cardinals rank 19th in the NFL. Defensively, they rank 25th, surrendering 25.6 points per contest.

Jaguars vs. Cardinals Odds and Game Time

• Date: Sunday, November 23, 2025
• Time: 4:05 p.m. ET
• City: Glendale, Arizona
• Venue: State Farm Stadium
• Total: 47.5 points
• Spread: Jaguars -2.5
• Moneyline: Jaguars (-148), Cardinals (+124)

How to watch Jaguars vs. Cardinals

• TV Channel: CBS (WFRV-Green Bay-Appleton, WI)
• Live Stream: Fubo

Betting the Over/Under: Jaguars vs. Cardinals

• Jaguars games this season have featured more combined points than this contest's total of 47.5 points four times.
• Jacksonville and its opponent have combined to go over the point total five out of 10 times this season.
• The Cardinals have played five games this season that finished with a point total above 47.5 points.
• In 2025, six Arizona games have hit the over.
• The teams average 46.4 points per game combined, 1.1 fewer than this matchup's total.
• These teams give up 48.2 points per game combined, 0.7 more points than the total for this contest.

Betting the Spread: Jaguars vs. Cardinals

• Jacksonville has won five games against the spread this season, while failing to cover five times.
• Jacksonville has covered the spread when playing as at least 2.5-point favorites in their only opportunity this season.
• The Cardinals have put together a 5-5-0 ATS record so far this year.
• When playing as at least 2.5-point underdogs this season, Arizona has an ATS record of 3-2.
• The Cardinals have one win against the spread, and are 1-4 overall, at home this year.
• At home, Arizona has one win ATS (1-1) as 2.5-point underdogs or more.
• On the road, the Jaguars have only one win against the spread and are 2-2 overall.

Betting the Moneyline: Jaguars vs. Cardinals

• Jacksonville has gone 3-1 in games they were favored on the moneyline (winning 75% of those games).
• The Cardinals have been underdogs in seven games this season and won one (14.3%) of those contests.
• Jacksonville has played as a moneyline favorite of -148 or shorter in just one game this season, which it won.
• Arizona has a record of 1-4 when it is set as an underdog of +124 or more by sportsbooks this season.
• The implied moneyline probability for this matchup gives the Jaguars a 59.7% chance to win.

Dunkel Prediction for Jaguars vs. Cardinals

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