Iowa State vs. St. John's Dunkel Predictions & Vegas Odds - Nov. 24

The No. 16 Iowa State Cyclones (4-0) host the No. 14 St. John's Red Storm (3-1) at Michelob ULTRA Arena, tipping off at 4:30 p.m. ET on Monday, November 24, 2025. The Cyclones are 2.5-point favorites in the game. The matchup's over/under is set at 161.5.

Iowa State is coming off of a 96-57 win against Stonehill in its last game on Monday. In Iowa State's win, Joshua Jefferson led the way with a team-high 23 points (adding nine rebounds and seven assists). St. John's most recent contest on Thursday ended in a 97-49 victory against Bucknell. Bryce Hopkins scored a team-leading 20 points for St. John's in the win.

Iowa State vs. St. John's Odds and Game Time

• When: Monday, November 24, 2025 at 4:30 p.m. ET
• Where: Michelob ULTRA Arena in Las Vegas, Nevada
• Spread favorite: Iowa State -2.5
• Moneyline favorite: Iowa State -143
• Moneyline underdog: St. John's +119
• Over/Under: 161.5 points

How to watch Iowa State vs. St. John's

• TV Channel: truTV
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Iowa State vs. St. John's

• Last year, Iowa State's games went over 161.5 points scored, its current matchup's total, 10 (out of 35) times.
• Six of St. John's 36 games last season had more than 161.5 total points scored.
• The two teams averaged a combined 2.7 fewer points per game (158.8) a season ago than this game's total of 161.5 points.
• Opponents of the two teams averaged a combined 27.4 fewer points per game (134.1) last season than this matchup's total of 161.5 points.
• The average point total in Iowa State's games last year was 12.8 fewer points than the total of 161.5 in this matchup.
• The average over/under for St. John's games in 2024 was 17.2 fewer points than the point total of 161.5 for this game.

Betting the Spread: Iowa State vs. St. John's

• Iowa State compiled a 20-15-0 ATS record last year.
• The Cyclones were favored by 2.5 points or more 30 times last season, and covered the spread in 17 of those contests.
• St. John's compiled a 23-12-1 ATS record last year.
• When playing as at least 2.5-point underdogs last season, the Red Storm had an ATS record of 3-0.
• At home last season, Iowa State was 15-2 overall and 9-8 against the spread.
• As a 2.5-point favorite or greater at home last year, Iowa State was 9-8 ATS.
• Away from home last season, St. John's was 8-2 overall and 7-2-1 against the spread.
• St. John's went 4-1 ATS as a 2.5-point underdog or more away from home.

Betting the Moneyline: Iowa State vs. St. John's

• Iowa State won 23 of the 29 games it was favored on the moneyline last season (79.3%).
• In games they played as a moneyline favorite with odds of -143 or shorter, the Cyclones had a 23-6 record (winning 79.3% of their games).
• The implied moneyline probability in this matchup gives Iowa State a 58.8% chance to win.
• St. John's was an underdog four times last season and won twice.
• Last season, the Red Storm won two of their three games when they were an underdog by at least +119 on the moneyline.
• The moneyline for this contest implies a 45.7% chance of a victory for St. John's.