Iowa State vs. Mississippi State Dunkel Predictions & Vegas Odds - Nov. 10

The No. 16 Iowa State Cyclones (2-0) take the court against the Mississippi State Bulldogs (1-0) as 5.5-point favorites on Monday, November 10, 2025 at 8 p.m. ET on ESPNU. The over/under is set at 150.5 in the matchup.

Iowa State heads into this contest following a 102-62 victory against Grambling on Thursday. Joshua Jefferson scored a team-best 20 points for Iowa State in the win. In its last outing on Wednesday, Mississippi State earned an 86-62 victory against North Alabama. Josh Hubbard's team-high 27 points paced Mississippi State in the win.

Iowa State vs. Mississippi State Odds and Game Time

• When: Monday, November 10, 2025 at 8 p.m. ET
• Where: Sanford Pentagon in Sioux Falls, South Dakota
• Spread favorite: Iowa State -5.5
• Moneyline favorite: Iowa State -220
• Moneyline underdog: Mississippi State +181
• Over/Under: 150.5 points

How to watch Iowa State vs. Mississippi State

• TV Channel: ESPN U
• Live Stream: Fubo
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Iowa State vs. Mississippi State

• Iowa State's games went over 150.5 points scored, its current matchup's total, 15 times (out of 35) last year.
• Mississippi State's games went over 150.5 total points scored in 19 of 34 matchups last year.
• The two teams averaged a combined 9.3 more points per game (159.8) a season ago than this matchup's total of 150.5 points.
• The Cyclones and the Bulldogs saw their opponents average a combined 8.0 fewer points per game last season than the point total of 150.5 set for this matchup.
• The average total Iowa State had set in matchups last year was 1.8 fewer points than this outing's point total.
• Mississippi State's games in 2024 averaged an over/under of 153.7 points, 3.2 more than the point total in this matchup.

Betting the Spread: Iowa State vs. Mississippi State

• Iowa State compiled a 20-15-0 record against the spread last season.
• The Cyclones were 17-12 ATS last season when playing as at least 5.5-point favorites.
• Mississippi State covered 15 times in 34 chances against the spread last year.
• The Bulldogs did not cover the spread last year (0-3 ATS) when playing as at least 5.5-point underdogs.
• Iowa State was 9-8 against the spread, and 15-2 overall, at home last season.
• Last year, as a 5.5-point favorite or greater at home, Iowa State was 9-8 ATS.
• In away games last season, Mississippi State was 6-5 overall and 6-5 against the spread.
• Away from home, Mississippi State was winless ATS (0-1) as a 5.5-point underdog or more.

Betting the Moneyline: Iowa State vs. Mississippi State

• Iowa State was the moneyline favorite 29 total times last season. It finished 23-6 in those games.
• When playing as a moneyline favorite with odds of -220 or shorter, the Cyclones had a 23-5 record (winning 82.1% of their games).
• Based on this matchup's moneyline, Iowa State has an implied win probability of 68.8%.
• Last season, Mississippi State won two out of the seven games in which it was the underdog.
• Last season, the Bulldogs were at least a +181 underdog on the moneyline three times, losing each of those contests.
• Bookmakers have implied with the moneyline set for this matchup that Mississippi State has a 35.6% chance to win.