Duke vs. Cal Dunkel NCAA Football Picks, Predictions and Odds - Oct. 4

The Duke Blue Devils (3-2) are favored by 3 points when they hit the road to play the California Golden Bears (4-1) in ACC action on Saturday, October 4, 2025 at California Memorial Stadium.

The Blue Devils' most recent contest was versus the Syracuse Orange, and they won by a score of 38-3.

Against the Boston College Eagles in their last game, the Golden Bears won 28-24.

Duke vs. Cal Predictions

For predictions on the upcoming contest between the Duke Blue Devils and California Golden Bears, computer-calculated against-the-spread, over/under, and score predictions are below, per Dunkel Index.

• Pick ATS: Blue Devils (- 3)
• Pick OU: Over (54.5)
  
• Prediction: Blue Devils 42 - Golden Bears 19

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Duke vs. Cal Moneylines

Take a look below at the most recent moneylines for the Blue Devils-Golden Bears matchup.

• Duke Moneyline: -162
• Cal Moneyline: +136

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Duke Betting Insights

• Duke has won all three of the games it has been listed as the moneyline favorite this season.
• Duke has played as a moneyline favorite of -162 or shorter in only two games this season, and it won both.
• The Blue Devils and their opponents have gone over 54.5 combined points in four of five games this season.
• Blue Devils matchups this year have an average total of 53.9, 0.6 fewer points than this game's over/under.
• The Blue Devils score the 40th-most points in college football this season, while the Golden Bears' offense racks up the 95th-most.

Cal Betting Insights

• Cal has won both games it has played as underdogs this season.
• Cal has played as an underdog of +136 or more once this season and won that game.
• Cal has not played a game this season that finished with a combined score over 54.5 points.
• The average total for Cal's games this season is 48.9 points, 5.6 fewer points than this game's over/under.

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Key Stats for Duke vs. Cal

• The Blue Devils rank 100th in total defense this season (393.8 yards allowed per game), but they've been playing really well on the offensive side of the ball, ranking 16th-best in the FBS with 471.8 total yards per game.
• Duke ranks 42nd in scoring offense (34.8 points per game) and 87th in scoring defense (26.4 points allowed per game) this year.
• In terms of total offense, the Golden Bears rank 85th in the FBS (364.8 total yards per game) and 31st on defense (307.2 total yards allowed per game).
• From an offensive standpoint, Cal is generating 24.8 points per contest (92nd-ranked). It ranks 32nd in the FBS on defense (18 points allowed per game).