NFL Predictions & Betting Odds - Week 4
23 September 2025
The Baltimore Ravens and the Kansas City Chiefs hit the field in one of many exciting matchups on the NFL schedule in Week 4.
We've got your back with a quick rundown on every NFL contest this week with over/unders, spreads, moneylines, and Dunkel Index predictions. Continue scrolling for the details.
Bet now!Week 4 Games, Betting Info, and Predictions
There are 16 games on the NFL docket this week. Here's a peek at each one:
Seattle Seahawks (3-1) at Arizona Cardinals (2-2)
- Game Time: 8:15 p.m. ET | Thursday, September 25, 2025
- Venue: State Farm Stadium (Glendale, Arizona)
- Total: 43.5
- Spread: Seahawks (-1.5)
- Moneyline: Seahawks (-130), Cardinals (+110)
Dunkel Index predictions:
- Over/Under: Over (43.5)
- ATS: Cardinals (+1.5)
- Score Prediction: Cardinals 24, Seahawks 21
Minnesota Vikings (2-1) at Pittsburgh Steelers (2-1)
- Game Time: 9:30 a.m. ET | Sunday, September 28, 2025
- Venue: Croke Park (Dublin, Ireland)
- Total: 41.5
- Spread: Vikings (-2.5)
- Moneyline: Vikings (-142), Steelers (+120)
Dunkel Index predictions:
- Over/Under: Over (41.5)
- ATS: Vikings (-2.5)
- Score Prediction: Vikings 24, Steelers 20
New Orleans Saints (0-3) at Buffalo Bills (3-0)
- Game Time: 1 p.m. ET | Sunday, September 28, 2025
- Venue: Highmark Stadium (Orchard Park, New York)
- Total: 48.5
- Spread: Bills (-15.5)
- Moneyline: Bills (-1449), Saints (+850)
Dunkel Index predictions:
- Over/Under: Under (48.5)
- ATS: Bills (-15.5)
- Score Prediction: Bills 34, Saints 14
Carolina Panthers (1-2) at New England Patriots (1-2)
- Game Time: 1 p.m. ET | Sunday, September 28, 2025
- Venue: Gillette Stadium (Foxborough, Massachusetts)
- Total: 42.5
- Spread: Patriots (-5.5)
- Moneyline: Patriots (-225), Panthers (+185)
Dunkel Index predictions:
- Over/Under: Over (42.5)
- ATS: Patriots (-5.5)
- Score Prediction: Patriots 26, Panthers 20
Philadelphia Eagles (3-0) at Tampa Bay Buccaneers (3-0)
- Game Time: 1 p.m. ET | Sunday, September 28, 2025
- Venue: Raymond James Stadium (Tampa, Florida)
- Total: 44.5
- Spread: Eagles (-3.5)
- Moneyline: Eagles (-198), Buccaneers (+164)
Dunkel Index predictions:
- Over/Under: Over (44.5)
- ATS: Buccaneers (+3.5)
- Score Prediction: Eagles 25, Buccaneers 24
Cleveland Browns (1-2) at Detroit Lions (2-1)
- Game Time: 1 p.m. ET | Sunday, September 28, 2025
- Venue: Ford Field (Detroit, Michigan)
- Total: 44.5
- Spread: Lions (-9.5)
- Moneyline: Lions (-535), Browns (+400)
Dunkel Index predictions:
- Over/Under: Over (44.5)
- ATS: Lions (-9.5)
- Score Prediction: Lions 39, Browns 9
Washington Commanders (2-1) at Atlanta Falcons (1-2)
- Game Time: 1 p.m. ET | Sunday, September 28, 2025
- Venue: Mercedes-Benz Stadium (Atlanta, Georgia)
- Total: 45.5
- Spread: Commanders (-1.5)
- Moneyline: Commanders (-125), Falcons (+105)
Dunkel Index predictions:
- Over/Under: Over (45.5)
- ATS: Commanders (-1.5)
- Score Prediction: Commanders 27, Falcons 23
Los Angeles Chargers (3-0) at New York Giants (0-3)
- Game Time: 1 p.m. ET | Sunday, September 28, 2025
- Venue: MetLife Stadium (East Rutherford, New Jersey)
- Total: 44.5
- Spread: Chargers (-6)
- Moneyline: Chargers (-270), Giants (+220)
Dunkel Index predictions:
- Over/Under: Under (44.5)
- ATS: Chargers (-6)
- Score Prediction: Chargers 27, Giants 14
Tennessee Titans (0-3) at Houston Texans (0-3)
- Game Time: 1 p.m. ET | Sunday, September 28, 2025
- Venue: NRG Stadium (Houston, Texas)
- Total: 38.5
- Spread: Texans (-7)
- Moneyline: Texans (-395), Titans (+310)
Dunkel Index predictions:
- Over/Under: Over (38.5)
- ATS: Texans (-7)
- Score Prediction: Texans 30, Titans 14
Indianapolis Colts (3-0) at Los Angeles Rams (2-1)
- Game Time: 4:05 p.m. ET | Sunday, September 28, 2025
- Venue: SoFi Stadium (Inglewood, California)
- Total: 50.5
- Spread: Rams (-3.5)
- Moneyline: Rams (-192), Colts (+160)
Dunkel Index predictions:
- Over/Under: Under (50.5)
- ATS: Rams (-3.5)
- Score Prediction: Rams 29, Colts 17
Jacksonville Jaguars (2-1) at San Francisco 49ers (3-0)
- Game Time: 4:05 p.m. ET | Sunday, September 28, 2025
- Venue: Levi's Stadium (Santa Clara, California)
- Total: 47.5
- Spread: 49ers (-3.5)
- Moneyline: 49ers (-180), Jaguars (+150)
Dunkel Index predictions:
- Over/Under: Under (47.5)
- ATS: 49ers (-3.5)
- Score Prediction: 49ers 28, Jaguars 19
Chicago Bears (1-2) at Las Vegas Raiders (1-2)
- Game Time: 4:25 p.m. ET | Sunday, September 28, 2025
- Venue: Allegiant Stadium (Paradise, Nevada)
- Total: 48.5
- Spread: Raiders (-1.5)
- Moneyline: Raiders (-115), Bears (-105)
Dunkel Index predictions:
- Over/Under: Under (48.5)
- ATS: Bears (+1.5)
- Score Prediction: Raiders 22, Bears 20
Baltimore Ravens (1-2) at Kansas City Chiefs (1-2)
- Game Time: 4:25 p.m. ET | Sunday, September 28, 2025
- Venue: GEHA Field at Arrowhead Stadium (Kansas City, Missouri)
- Total: 49.5
- Spread: Ravens (-2.5)
- Moneyline: Ravens (-148), Chiefs (+124)
Dunkel Index predictions:
- Over/Under: Under (49.5)
- ATS: Chiefs (+2.5)
- Score Prediction: Ravens 24, Chiefs 23
Green Bay Packers (2-1) at Dallas Cowboys (1-2)
- Game Time: 8:20 p.m. ET | Sunday, September 28, 2025
- Venue: AT&T Stadium (Arlington, Texas)
- Total: 47.5
- Spread: Packers (-6.5)
- Moneyline: Packers (-355), Cowboys (+280)
Dunkel Index predictions:
- Over/Under: Under (47.5)
- ATS: Packers (-6.5)
- Score Prediction: Packers 29, Cowboys 18
New York Jets (0-3) at Miami Dolphins (0-3)
- Game Time: 7:15 p.m. ET | Monday, September 29, 2025
- Venue: Hard Rock Stadium (Miami Gardens, Florida)
- Total: 45.5
- Spread: Dolphins (-2.5)
- Moneyline: Dolphins (-155), Jets (+130)
Dunkel Index predictions:
- Over/Under: Under (45.5)
- ATS: Dolphins (-2.5)
- Score Prediction: Dolphins 24, Jets 19
Cincinnati Bengals (2-1) at Denver Broncos (1-2)
- Game Time: 8:15 p.m. ET | Monday, September 29, 2025
- Venue: Empower Field at Mile High (Denver, Colorado)
- Total: 44.5
- Spread: Broncos (-7.5)
- Moneyline: Broncos (-426), Bengals (+330)
Dunkel Index predictions:
- Over/Under: Over (44.5)
- ATS: Broncos (-7.5)
- Score Prediction: Broncos 29, Bengals 19
