Penn State vs. UCLA Dunkel NCAA Football Picks, Predictions and Odds - Oct. 4

Big Ten rivals meet when the No. 7 Penn State Nittany Lions (3-1) visit the UCLA Bruins (0-4) on Saturday, October 4, 2025 at the Rose Bowl. Penn State is favored by 24.5 points.

The Nittany Lions lost versus the Oregon Ducks in their last game, 30-24.

The Bruins lost versus the Northwestern Wildcats in their last game, 17-14.

Penn State vs. UCLA Predictions

For predictions on the upcoming game between the Penn State Nittany Lions and UCLA Bruins, computer-derived against-the-spread, over/under, and score predictions are below, per Dunkel Index.

• Pick ATS: Nittany Lions (- 24.5)
• Pick OU: Over (49.5)
  
• Prediction: Nittany Lions 45 - Bruins 10

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Penn State vs. UCLA Moneylines

Snag a look below at the most up-to-date moneylines for the Nittany Lions-Bruins matchup.

• Penn State Moneyline: -2941
• UCLA Moneyline: +1300

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Penn State Betting Insights

• Penn State has been the moneyline favorite only two other times so far this season, and they split the two games.
• Penn State has played as a moneyline favorite of -2941 or shorter in only one game this season, which it won.
• The Nittany Lions four games this season have gone over this contest's total of 49.5 points three times.
• The average total in Nittany Lions outings this year is 54.3, 4.8 more than this matchup's over/under.
• The Bruins are college football's 134th-highest scoring team this season compared to the 34th-ranked Nittany Lions.

UCLA Betting Insights

• UCLA has lost both games it has played as underdogs this season.
• UCLA has not entered a game this season with longer moneyline odds than +1300.
• UCLA and its opponents have combined to score more than 49.5 points twice this season.
• UCLA's contests this season have a 50.8-point average over/under, 1.3 more points than this game's total.

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Key Stats for Penn State vs. UCLA

• Defensively, the Nittany Lions have been a top-25 unit, ranking 19th-best by surrendering only 274.0 yards per game. They rank 67th on offense (397.0 yards per game).
• Penn State has been firing on all cylinders this year, as they rank 18th-best in scoring offense (39.0 points per game) and 10th-best in scoring defense (11.8 points allowed per game).
• The Bruins' offense has been a bottom-25 unit in total offense this season, generating 321.3 total yards per game, which ranks 18th-worst in the FBS. On the defensive side of the ball, they rank 107th with 401.8 total yards surrendered per contest.
• UCLA has plenty of room to improve, as it ranks third-worst in points per game (14.3) this season and 18th-worst in points surrendered per game (31.3).