Cubs vs. Reds Dunkel MLB Picks, Predictions and Prop Bets - May 6

The Chicago Cubs aim to continue their seven-game win streak when they take on the Cincinnati Reds on Wednesday at 7:40 p.m. ET, at Wrigley Field. Colin Rea (4-1, 4.41 ERA) gets the start for the Cubs, who are 24-12 this season and first in the NL Central. Brady Singer (2-2, 5.57 ERA) is expected to start for the Reds, who are 20-16 and third in the NL Central.

The Reds (+144) are on the road versus the favored Cubs (-172). The game's total is set at 8.

Cubs vs. Reds Odds, Game Time

• Game day: Wednesday, May 6, 2026
• Game time: 7:40 p.m. ET
• Location: Chicago, Illinois
• Stadium: Wrigley Field
• Favorite: Cubs (-172)
• Underdog: Reds (+144)
• Over/under: 8

How to Watch Cubs vs. Reds

• TV Channel: MARQ and CINR
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Cubs vs. Reds: Betting the Moneyline

• The Cubs have gone 17-7 in games they were listed as the moneyline favorite (winning 70.8% of those games).
• Cincinnati has been victorious in 14, or 53.8%, of the 26 contests it has been chosen as underdogs in this season.
• Chicago is 4-2 this season when entering a game favored by -172 or more on the moneyline.
• The Reds have played as an underdog of +144 or more just one time this year and came away with a loss in that game.
• The implied moneyline probablility in this matchup gives the Cubs a 63.2% chance to win.
• Sportsbooks have implied with the moneyline set for this matchup that the Reds have a 41% chance of pulling out a win.

Cubs vs. Reds: Betting the Spread & Total

• The Cubs have had an over/under set by oddsmakers 36 times, and have combined with opponents to go over the total in 22 of those games (22-12-2).
• Cincinnati and its opponents have gone over the total this season in 21 of its 36 opportunities.
• The Cubs have a 17-19-0 record against the spread this season (covering 47.2% of the time).
• The Reds have posted a record of 23-13-0 against the spread this season.