Guardians vs. Reds Dunkel MLB Picks, Predictions and Prop Bets - May 16

Matt McLain rides a two-game homer streak into the Cincinnati Reds' game versus the Cleveland Guardians at 6:10 p.m. ET on Saturday, at Progressive Field. Joey Cantillo (3-1, 2.98 ERA) gets the start for the Guardians, who are 24-22 this season and first in the AL Central. Chris Paddack (0-5, 7.63 ERA) is the expected starter for the Reds, who are 24-21 and fifth in the NL Central.

The bookmakers have spoken, making the Guardians (-155) a moderate moneyline favorite to beat the Reds (+129) at home. The total for the Guardians-Reds game is 8.5.

Guardians vs. Reds Odds, Game Time

• Game day: Saturday, May 16, 2026
• Game time: 6:10 p.m. ET
• Location: Cleveland, Ohio
• Stadium: Progressive Field
• Favorite: Guardians (-155)
• Underdog: Reds (+129)
• Over/under: 8.5

How to Watch Guardians vs. Reds

• TV Channel: CLEG and CINR
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Guardians vs. Reds: Betting the Moneyline

• The Guardians have won 52% of the games this season when they were favored on the moneyline (13-12).
• Cincinnati has been victorious in 15, or 51.7%, of the 29 contests it has been chosen as underdogs in this season.
• Cleveland has a record of 2-2 in games when sportsbooks favor them by at least -155 on the moneyline.
• The Reds have a win-loss record of 2-5 when favored by +129 or worse by bookmakers this year.
• The implied moneyline probablility for this matchup gives the Guardians a 60.8% chance to win.
• The moneyline set for this matchup implies the Reds have a 43.7% chance of walking away with the win.

Guardians vs. Reds: Betting the Spread & Total

• The Guardians have played in 46 games with an over/under set, and have combined with their opponents to go over the total 23 times (23-23-0).
• Cincinnati and its opponents have hit the over in 28 of its 45 games with a total this season.
• The Guardians are 25-21-0 against the spread this season.
• The Reds have posted a record of 28-17-0 against the spread this season.