Clemson vs. American Dunkel Predictions & Vegas Odds - Nov. 6

The Clemson Tigers (1-0) host the American Eagles (0-1) at Littlejohn Coliseum, tipping off at 7 p.m. ET on Friday, November 6, 2026. The Tigers are 17.5-point favorites in the game. The matchup has an over/under of 143.5 points.

Last time out, Clemson won on Monday 85-72 over Stetson. Ace Buckner's team-high 20 points led Clemson in the victory. American's most recent game was a 79-53 loss to Cincinnati on Monday. Madden Collins totaled 20 points, two rebounds and one assist for American.

Clemson vs. American Odds and Game Time

• When: Friday, November 6, 2026 at 7 p.m. ET
• Where: Littlejohn Coliseum in Clemson, South Carolina
• Spread favorite: Clemson -17.5
• Moneyline favorite: Clemson -4000
• Moneyline underdog: American +1438
• Over/Under: 143.5 points

How to watch Clemson vs. American

• TV Channel: ACC Network Extra
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Clemson vs. American

• Clemson and its opponent combined to score over 143.5 points, the current matchup's over/under, in 11 of 35 games last year.
• Last season, 16 of American's 30 games had a combined total higher than 143.5 points scored.
• The Tigers and the Eagles combined to average 4.9 more points per game a season ago than the over/under of 143.5 set for this matchup.
• Opponents of the two teams averaged a combined 5.5 fewer points per game (138) last season than this game's total of 143.5 points.
• The average over/under Clemson had set in matchups last year was 3.0 fewer points than this outing's point total.
• The average point total for American in 2025 was 2.4 points higher than this game's over/under.

Betting the Spread: Clemson vs. American

• Clemson went 15-19-1 ATS last season.
• The Tigers covered the spread three times last season (3-3 ATS) when playing as at least 17.5-point favorites.
• American compiled a 16-14-0 ATS record last year.
• The Eagles were an underdog by 17.5 points or more four times last season, and covered the spread in one of those matchups.
• Clemson was 6-9-1 against the spread, and 13-3 overall, at home last year.
• At home last season, as a 17.5-point favorite or greater, Clemson was 3-3 ATS.
• In away games last season, American was 8-7 against the spread and 5-9 overall.

Betting the Moneyline: Clemson vs. American

• Clemson went 23-5 in games it was favored on the moneyline last season (winning 82.1% of those games).
• The Tigers won all six games they played as a moneyline favorite with odds of -4000 or shorter.
• Clemson has a 97.6% chance to win this game based on the moneyline's implied probability.
• American won two, or 18.2%, of the 11 games it played as underdogs last season.
• The Eagles played as an underdog of +1438 or more twice last season and lost both games.
• The bookmakers' moneyline implies a 6.5% chance of a victory for American.