Bills vs. Texans Week 12 Dunkel NFL Picks, Predictions and Odds

The Buffalo Bills (7-3) are favored by 5.5 points against the Houston Texans (5-5) on November 20, 2025, starting at 8:15 p.m. ET, airing on Amazon Prime Video. The total for this one is set at 43.5 points.

The Bills own the 14th-ranked defense this year (22.9 points allowed per game), and they've been better on offense, ranking fourth-best with 29.2 points per game. The Texans rank 19th in the NFL with 329.6 total yards per game, but they've been lifted up by their defense, which ranks best by giving up only 258.1 total yards per game.

Bills vs. Texans Odds and Game Time

• Date: Thursday, November 20, 2025
• Time: 8:15 p.m. ET
• City: Houston, Texas
• Venue: NRG Stadium
• Total: 43.5 points
• Spread: Bills -5.5
• Moneyline: Bills (-298), Texans (+240)

How to watch Bills vs. Texans

• TV Channel: FOX (KRIV - Houston, TX)
• Live Stream: Fubo

Betting the Over/Under: Bills vs. Texans

• Bills games this season have featured more combined points than this contest's total of 43.5 points six times.
• In Buffalo's 10 games this season, the combined scoring has gone over the point total five times.
• The Texans have played three games this season that finished with a combined score higher than 43.5 points.
• In Houston's 10 contests this year, the combined scoring has gone over the point total three times.
• The teams average 51.2 points per game combined, 7.7 more points than this game's total.
• Combined, these teams allow 39.2 points per game, 4.3 fewer points than this matchup's over/under.

Betting the Spread: Bills vs. Texans

• Buffalo has put together a 5-5-0 ATS record so far this year.
• Buffalo has been favored by 5.5 points or more seven times this season, and covered the spread in three of those games.
• The Texans have covered four times in 10 matchups with a spread this year.
• The Texans are 3-2 against the spread, and 3-2 overall, at home this year.
• The Bills are 2-2 overall with two wins against the spread on the road.
• On the road, Buffalo has two wins ATS (2-1) as 5.5-point favorites or more.

Betting the Moneyline: Bills vs. Texans

• Buffalo has won five of the eight games it was the moneyline favorite this season (62.5%).
• This season, the Texans have won one out of the four games in which they've been the underdog.
• When it has played as a moneyline favorite with odds of -298 or shorter, Buffalo has a 3-2 record (winning 60% of its games).
• Houston has not been a bigger underdog this season than the +240 moneyline set for this game.
• The implied moneyline probability in this matchup gives the Bills a 74.9% chance to win.

Dunkel Prediction for Bills vs. Texans

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