Falcons vs. Cardinals Week 16 Dunkel NFL Picks, Predictions and Odds

The Arizona Cardinals (3-11) will be aiming to snap a six-game losing streak against the Atlanta Falcons (5-9). The Falcons are slim favorites (-2.5). The predicted point total for the game is 48.5.

The Falcons rank 14th in total offense (340.4 yards per game) and 14th in total defense (323.6 yards allowed per game) this season. The Cardinals rank 17th with 333.4 total yards per contest on offense, and they rank 26th with 351.1 total yards surrendered per game on defense.

Falcons vs. Cardinals Odds and Game Time

• Date: Sunday, December 21, 2025
• Time: 4:05 p.m. ET
• City: Glendale, Arizona
• Venue: State Farm Stadium
• Total: 48.5 points
• Spread: Falcons -2.5
• Moneyline: Falcons (-148), Cardinals (+124)

How to watch Falcons vs. Cardinals

• TV Channel: FOX (KMSB-Tuscon, AZ)
• Live Stream: Fubo

Betting the Over/Under: Falcons vs. Cardinals

• The Falcons and their opponents have scored more than 48.5 total points five times this season.
• Atlanta games have hit the over seven out of 14 times this season.
• The Cardinals have combined with their opponent to score more than 48.5 points in eight of 14 games this season.
• So far this season, nine of Arizona's 14 games with a set number have hit the over.
• The two teams combine to score 41.7 points per game, 6.8 fewer points than this matchup's total.
• Opponents of these two teams average 52.1 points per game combined, 3.6 more points than this matchup's over/under.

Betting the Spread: Falcons vs. Cardinals

• Atlanta has compiled a 7-7-0 record against the spread this season.
• Atlanta has covered the spread once when favored by 2.5 points or more this season (in five opportunities).
• The Cardinals have won six games against the spread this year, failing to cover eight times.
• Arizona is 4-5 ATS this year when playing as at least 2.5-point underdogs.
• At home this season, the Cardinals have one win against the spread and are 1-6 overall.
• At home, as 2.5-point underdogs or more, Arizona has one win ATS (1-3).
• In away games, the Falcons are 3-5 overall and 5-3 against the spread.
• On the road, Atlanta is winless ATS (0-2) as 2.5-point favorites or more.

Betting the Moneyline: Falcons vs. Cardinals

• Atlanta has compiled a 1-4 record in games they were favored on the moneyline (winning 20% of those games).
• This season, the Cardinals have been the underdog 11 times and won one of those games.
• Atlanta has played in four games as a moneyline favorite with odds of -148 or shorter without a win.
• Arizona has entered eight games this season as the underdog by +124 or more and is 1-7 in those contests.
• The Falcons have a 59.7% chance to win this contest based on the moneyline's implied probability.

Dunkel Prediction for Falcons vs. Cardinals

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