NFL Predictions & Betting Odds - Week 16
16 December 2025
The Week 16 NFL slate has plenty of exciting matchups on the docket. Among those contests is the Los Angeles Rams taking on the Seattle Seahawks.
We've got your back with a fast rundown on every NFL tilt this week with over/unders, spreads, moneylines, and Dunkel Index predictions. Continue scrolling for the key information.
Bet now on FanDuel Sportsbook!Week 16 Games, Betting Info, and Predictions
There are 16 games on the NFL schedule this week. Below is a peek at each matchup:
Los Angeles Rams (11-4) at Seattle Seahawks (12-3)
- Game Time: 8:15 p.m. ET | Thursday, December 18, 2025
- Venue: Lumen Field (Seattle, Washington)
- Total: 42.5
- Spread: Seahawks (-1.5)
- Moneyline: Seahawks (-122), Rams (+102)
Dunkel Index predictions:
- Over/Under: Over (42.5)
- ATS: Rams (+1.5)
- Score Prediction: Seahawks 25, Rams 24
Philadelphia Eagles (10-5) at Washington Commanders (4-11)
- Game Time: 5 p.m. ET | Saturday, December 20, 2025
- Venue: Northwest Stadium (Landover, Maryland)
- Total: 43.5
- Spread: Eagles (-7.5)
- Moneyline: Eagles (-380), Commanders (+300)
Dunkel Index predictions:
- Over/Under: Over (43.5)
- ATS: Eagles (-7.5)
- Score Prediction: Eagles 28, Commanders 17
Green Bay Packers (9-5-1) at Chicago Bears (11-4)
- Game Time: 8:20 p.m. ET | Saturday, December 20, 2025
- Venue: Soldier Field (Chicago, Illinois)
- Total: 45.5
- Spread: Bears (-1.5)
- Moneyline: Bears (-120), Packers (+100)
Dunkel Index predictions:
- Over/Under: Over (45.5)
- ATS: Bears (-1.5)
- Score Prediction: Bears 25, Packers 23
Los Angeles Chargers (11-4) at Dallas Cowboys (6-8-1)
- Game Time: 1 p.m. ET | Sunday, December 21, 2025
- Venue: AT&T Stadium (Arlington, Texas)
- Total: 51.5
- Spread: Cowboys (-1.5)
- Moneyline: Cowboys (-122), Chargers (+102)
Dunkel Index predictions:
- Over/Under: Under (51.5)
- ATS: Chargers (+1.5)
- Score Prediction: Chargers 26, Cowboys 25
Buffalo Bills (11-4) at Cleveland Browns (3-12)
- Game Time: 1 p.m. ET | Sunday, December 21, 2025
- Venue: Huntington Bank Field (Cleveland, Ohio)
- Total: 41.5
- Spread: Bills (-10.5)
- Moneyline: Bills (-575), Browns (+425)
Dunkel Index predictions:
- Over/Under: Over (41.5)
- ATS: Bills (-10.5)
- Score Prediction: Bills 31, Browns 15
Cincinnati Bengals (5-10) at Miami Dolphins (6-9)
- Game Time: 1 p.m. ET | Sunday, December 21, 2025
- Venue: Hard Rock Stadium (Miami Gardens, Florida)
- Total: 48.5
- Spread: Bengals (-4.5)
- Moneyline: Bengals (-205), Dolphins (+170)
Dunkel Index predictions:
- Over/Under: Over (48.5)
- ATS: Dolphins (+4.5)
- Score Prediction: Dolphins 28, Bengals 21
Minnesota Vikings (7-8) at New York Giants (2-13)
- Game Time: 1 p.m. ET | Sunday, December 21, 2025
- Venue: MetLife Stadium (East Rutherford, New Jersey)
- Total: 41.5
- Spread: Vikings (-2.5)
- Moneyline: Vikings (-148), Giants (+124)
Dunkel Index predictions:
- Over/Under: Over (41.5)
- ATS: Giants (+2.5)
- Score Prediction: Vikings 24, Giants 23
New York Jets (3-12) at New Orleans Saints (5-10)
- Game Time: 1 p.m. ET | Sunday, December 21, 2025
- Venue: Caesars Superdome (New Orleans, Louisiana)
- Total: 40.5
- Spread: Saints (-6.5)
- Moneyline: Saints (-298), Jets (+240)
Dunkel Index predictions:
- Over/Under: Over (40.5)
- ATS: Saints (-6.5)
- Score Prediction: Saints 27, Jets 17
Tampa Bay Buccaneers (7-8) at Carolina Panthers (8-7)
- Game Time: 1 p.m. ET | Sunday, December 21, 2025
- Venue: Bank of America Stadium (Charlotte, North Carolina)
- Total: 44.5
- Spread: Buccaneers (-3)
- Moneyline: Buccaneers (-155), Panthers (+130)
Dunkel Index predictions:
- Over/Under: Over (44.5)
- ATS: Panthers (+3)
- Score Prediction: Buccaneers 23, Panthers 22
Kansas City Chiefs (6-9) at Tennessee Titans (3-12)
- Game Time: 1 p.m. ET | Sunday, December 21, 2025
- Venue: Nissan Stadium (Nashville, Tennessee)
- Total: 37.5
- Spread: Chiefs (-3.5)
- Moneyline: Chiefs (-185), Titans (+154)
Dunkel Index predictions:
- Over/Under: Over (37.5)
- ATS: Chiefs (-3.5)
- Score Prediction: Chiefs 25, Titans 18
Atlanta Falcons (6-9) at Arizona Cardinals (3-12)
- Game Time: 4:05 p.m. ET | Sunday, December 21, 2025
- Venue: State Farm Stadium (Glendale, Arizona)
- Total: 48.5
- Spread: Falcons (-2.5)
- Moneyline: Falcons (-148), Cardinals (+124)
Dunkel Index predictions:
- Over/Under: Under (48.5)
- ATS: Cardinals (+2.5)
- Score Prediction: Cardinals 25, Falcons 22
Jacksonville Jaguars (11-4) at Denver Broncos (12-3)
- Game Time: 4:05 p.m. ET | Sunday, December 21, 2025
- Venue: Empower Field at Mile High (Denver, Colorado)
- Total: 46.5
- Spread: Broncos (-3.5)
- Moneyline: Broncos (-175), Jaguars (+145)
Dunkel Index predictions:
- Over/Under: Under (46.5)
- ATS: Jaguars (+3.5)
- Score Prediction: Jaguars 23, Broncos 22
Pittsburgh Steelers (9-6) at Detroit Lions (8-7)
- Game Time: 4:25 p.m. ET | Sunday, December 21, 2025
- Venue: Ford Field (Detroit, Michigan)
- Total: 52.5
- Spread: Lions (-7.5)
- Moneyline: Lions (-410), Steelers (+320)
Dunkel Index predictions:
- Over/Under: Under (52.5)
- ATS: Steelers (+7.5)
- Score Prediction: Lions 29, Steelers 22
Las Vegas Raiders (2-13) at Houston Texans (10-5)
- Game Time: 4:25 p.m. ET | Sunday, December 21, 2025
- Venue: NRG Stadium (Houston, Texas)
- Total: 39.5
- Spread: Texans (-14)
- Moneyline: Texans (-1587), Raiders (+900)
Dunkel Index predictions:
- Over/Under: Over (39.5)
- ATS: Texans (-14)
- Score Prediction: Texans 34, Raiders 6
New England Patriots (12-3) at Baltimore Ravens (7-8)
- Game Time: 8:20 p.m. ET | Sunday, December 21, 2025
- Venue: M&T Bank Stadium (Baltimore, Maryland)
- Total: 48.5
- Spread: Ravens (-3.5)
- Moneyline: Ravens (-198), Patriots (+164)
Dunkel Index predictions:
- Over/Under: Under (48.5)
- ATS: Patriots (+3.5)
- Score Prediction: Patriots 24, Ravens 22
San Francisco 49ers (10-4) at Indianapolis Colts (8-6)
- Game Time: 8:15 p.m. ET | Monday, December 22, 2025
- Venue: Lucas Oil Stadium (Indianapolis, Indiana)
- Total: 46.5
- Spread: 49ers (-4.5)
- Moneyline: 49ers (-230), Colts (+190)
Dunkel Index predictions:
- Over/Under: Over (46.5)
- ATS: Colts (+4.5)
- Score Prediction: Colts 24, 49ers 23
