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NFL Predictions & Betting Odds - Week 15

09 December 2025 By Data Skrive

The matchups in a Week 15 NFL lineup that shouldn't be missed include the Detroit Lions playing the Los Angeles Rams at SoFi Stadium.

We've got you covered with a quick rundown on every NFL tilt this week with over/unders, spreads, moneylines, and Dunkel Index predictions. Keep reading for the key information.

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Week 15 Games, Betting Info, and Predictions

There are 16 games on the pro football schedule this week. Here's a peek at each matchup:

Atlanta Falcons (5-9) at Tampa Bay Buccaneers (7-7)

  • Game Time: 8:15 p.m. ET | Thursday, December 11, 2025
  • Venue: Raymond James Stadium (Tampa, Florida)
  • Total: 43.5
  • Spread: Buccaneers (-5.5)
  • Moneyline: Buccaneers (-278), Falcons (+225)

Dunkel Index predictions:

  • Over/Under: Over (43.5)
  • ATS: Buccaneers (-5.5)
  • Score Prediction: Buccaneers 28, Falcons 18

Baltimore Ravens (7-7) at Cincinnati Bengals (4-10)

  • Game Time: 1 p.m. ET | Sunday, December 14, 2025
  • Venue: Paycor Stadium (Cincinnati, Ohio)
  • Total: 51.5
  • Spread: Ravens (-1.5)
  • Moneyline: Ravens (-162), Bengals (+136)

Dunkel Index predictions:

  • Over/Under: Over (51.5)
  • ATS: Bengals (+1.5)
  • Score Prediction: Ravens 27, Bengals 25

Arizona Cardinals (3-11) at Houston Texans (9-5)

  • Game Time: 1 p.m. ET | Sunday, December 14, 2025
  • Venue: NRG Stadium (Houston, Texas)
  • Total: 42.5
  • Spread: Texans (-10.5)
  • Moneyline: Texans (-625), Cardinals (+455)

Dunkel Index predictions:

  • Over/Under: Over (42.5)
  • ATS: Texans (-10.5)
  • Score Prediction: Texans 31, Cardinals 12

Las Vegas Raiders (2-12) at Philadelphia Eagles (9-5)

  • Game Time: 1 p.m. ET | Sunday, December 14, 2025
  • Venue: Lincoln Financial Field (Philadelphia, Pennsylvania)
  • Total: 37.5
  • Spread: Eagles (-12.5)
  • Moneyline: Eagles (-1000), Raiders (+650)

Dunkel Index predictions:

  • Over/Under: Over (37.5)
  • ATS: Eagles (-12.5)
  • Score Prediction: Eagles 31, Raiders 11

Washington Commanders (4-10) at New York Giants (2-12)

  • Game Time: 1 p.m. ET | Sunday, December 14, 2025
  • Venue: MetLife Stadium (East Rutherford, New Jersey)
  • Total: 46.5
  • Spread: Giants (-3)
  • Moneyline: Giants (-155), Commanders (+130)

Dunkel Index predictions:

  • Over/Under: Over (46.5)
  • ATS: Giants (-3)
  • Score Prediction: Giants 28, Commanders 21

Buffalo Bills (10-4) at New England Patriots (11-3)

  • Game Time: 1 p.m. ET | Sunday, December 14, 2025
  • Venue: Gillette Stadium (Foxborough, Massachusetts)
  • Total: 49.5
  • Spread: Bills (-2.5)
  • Moneyline: Bills (-142), Patriots (+120)

Dunkel Index predictions:

  • Over/Under: Under (49.5)
  • ATS: Patriots (+2.5)
  • Score Prediction: Patriots 26, Bills 23

New York Jets (3-11) at Jacksonville Jaguars (10-4)

  • Game Time: 1 p.m. ET | Sunday, December 14, 2025
  • Venue: EverBank Stadium (Jacksonville, Florida)
  • Total: 40.5
  • Spread: Jaguars (-14)
  • Moneyline: Jaguars (-1053), Jets (+675)

Dunkel Index predictions:

  • Over/Under: Over (40.5)
  • ATS: Jaguars (-14)
  • Score Prediction: Jaguars 34, Jets 12

Cleveland Browns (3-11) at Chicago Bears (10-4)

  • Game Time: 1 p.m. ET | Sunday, December 14, 2025
  • Venue: Soldier Field (Chicago, Illinois)
  • Total: 38.5
  • Spread: Bears (-7.5)
  • Moneyline: Bears (-380), Browns (+300)

Dunkel Index predictions:

  • Over/Under: Over (38.5)
  • ATS: Bears (-7.5)
  • Score Prediction: Bears 30, Browns 16

Los Angeles Chargers (10-4) at Kansas City Chiefs (6-8)

  • Game Time: 1 p.m. ET | Sunday, December 14, 2025
  • Venue: GEHA Field at Arrowhead Stadium (Kansas City, Missouri)
  • Total: 41.5
  • Spread: Chiefs (-4.5)
  • Moneyline: Chiefs (-265), Chargers (+215)

Dunkel Index predictions:

  • Over/Under: Over (41.5)
  • ATS: Chiefs (-4.5)
  • Score Prediction: Chiefs 24, Chargers 19

Green Bay Packers (9-4-1) at Denver Broncos (12-2)

  • Game Time: 4:25 p.m. ET | Sunday, December 14, 2025
  • Venue: Empower Field at Mile High (Denver, Colorado)
  • Total: 42.5
  • Spread: Packers (-1.5)
  • Moneyline: Packers (-122), Broncos (+102)

Dunkel Index predictions:

  • Over/Under: Over (42.5)
  • ATS: Broncos (+1.5)
  • Score Prediction: Broncos 24, Packers 19

Indianapolis Colts (8-6) at Seattle Seahawks (11-3)

  • Game Time: 4:25 p.m. ET | Sunday, December 14, 2025
  • Venue: Lumen Field (Seattle, Washington)
  • Total: 42.5
  • Spread: Seahawks (-13.5)
  • Moneyline: Seahawks (-1000), Colts (+650)

Dunkel Index predictions:

  • Over/Under: Over (42.5)
  • ATS: Colts (+13.5)
  • Score Prediction: Seahawks 30, Colts 19

Tennessee Titans (2-12) at San Francisco 49ers (10-4)

  • Game Time: 4:25 p.m. ET | Sunday, December 14, 2025
  • Venue: Levi's Stadium (Santa Clara, California)
  • Total: 44.5
  • Spread: 49ers (-12.5)
  • Moneyline: 49ers (-952), Titans (+625)

Dunkel Index predictions:

  • Over/Under: Under (44.5)
  • ATS: 49ers (-12.5)
  • Score Prediction: 49ers 32, Titans 12

Carolina Panthers (7-7) at New Orleans Saints (4-10)

  • Game Time: 4:25 p.m. ET | Sunday, December 14, 2025
  • Venue: Caesars Superdome (New Orleans, Louisiana)
  • Total: 41.5
  • Spread: Panthers (-2.5)
  • Moneyline: Panthers (-148), Saints (+124)

Dunkel Index predictions:

  • Over/Under: Under (41.5)
  • ATS: Saints (+2.5)
  • Score Prediction: Panthers 22, Saints 19

Detroit Lions (8-6) at Los Angeles Rams (11-3)

  • Game Time: 4:25 p.m. ET | Sunday, December 14, 2025
  • Venue: SoFi Stadium (Inglewood, California)
  • Total: 55.5
  • Spread: Rams (-5.5)
  • Moneyline: Rams (-238), Lions (+195)

Dunkel Index predictions:

  • Over/Under: Under (55.5)
  • ATS: Rams (-5.5)
  • Score Prediction: Rams 34, Lions 17

Minnesota Vikings (6-8) at Dallas Cowboys (6-7-1)

  • Game Time: 8:20 p.m. ET | Sunday, December 14, 2025
  • Venue: AT&T Stadium (Arlington, Texas)
  • Total: 48.5
  • Spread: Cowboys (-5.5)
  • Moneyline: Cowboys (-265), Vikings (+215)

Dunkel Index predictions:

  • Over/Under: Over (48.5)
  • ATS: Vikings (+5.5)
  • Score Prediction: Cowboys 27, Vikings 23

Miami Dolphins (6-7) at Pittsburgh Steelers (7-6)

  • Game Time: 8:15 p.m. ET | Monday, December 15, 2025
  • Venue: Acrisure Stadium (Pittsburgh, Pennsylvania)
  • Total: 42.5
  • Spread: Steelers (-3)
  • Moneyline: Steelers (-175), Dolphins (+145)

Dunkel Index predictions:

  • Over/Under: Over (42.5)
  • ATS: Steelers (-3)
  • Score Prediction: Steelers 26, Dolphins 20

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