Virginia vs. Duke Dunkel NCAA Football ACC Championship Picks, Predictions and Odds - Dec. 6

The Duke Blue Devils are the underdogs, but by less than a touchdown (+3.5), in this year's ACC Championship Game, where they will oppose the Virginia Cavaliers. Bank of America Stadium will host the matchup on December 6, 2025, starting at 8 p.m. ET on ABC.

Last time out, the Cavaliers defeated the Virginia Tech Hokies, with 27-7 being the final score.

The Blue Devils won versus the Wake Forest Demon Deacons in their most recent game, 49-32.

Virginia vs. Duke Predictions

For the upcoming game between the Virginia Cavaliers and Duke Blue Devils, computer-calculated against-the-spread, over/under, and score predictions are below, based on data from Dunkel Index.

• Pick ATS: Blue Devils (+ 3.5)
• Pick OU: Over (57.5)
  
• Prediction: Blue Devils 32 - Cavaliers 31

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Virginia vs. Duke Moneylines

Take a peek below at the most up-to-date moneylines for the Cavaliers-Blue Devils matchup.

• Virginia Moneyline: -183
• Duke Moneyline: +153

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Virginia Betting Insights

• Virginia has won 87.5% of the games this season when it was favored on the moneyline (7-1).
• Virginia has a 7-1 record (winning 87.5% of its games) when playing as a moneyline favorite of -183 or shorter.
• In four games this season, the Cavaliers and their opponents have scored more than 57.5 total points.
• Cavaliers games this season have had an average of 54.6 points, 2.9 fewer than this matchup's over/under.
• The Cavaliers are the 28th-highest scoring team in college football this year. The Blue Devils have scored the 19th-most points.

Duke Betting Insights

• Duke has entered the game as an underdog three times this season and won once.
• Duke has not entered a game this season as a bigger underdog on the moneyline than the +153 odds on them winning this game.
• Duke games this season have had a combined scoring total higher than 57.5 points in eight of 12 outings.
• Duke's games this season have had an average of 55.8 points, 1.7 fewer points than this game's total.

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Key Stats for Virginia vs. Duke

• Over their last four meetings, Virginia has tallied three wins against Duke.
• The Cavaliers have a 3-1 record ATS in those games, while the two teams have gone over the point total on one occasion.
• The Cavaliers sport the 26th-ranked offense this season (433.2 yards per game), and they've been even more effective on the other side of the ball, ranking 21st-best with only 312.3 yards allowed per game.
• On defense, Virginia has been a top-25 unit, ranking 24th-best by allowing only 20 points per game. The offense ranks 27th (33.2 points per game).
• The Blue Devils' defense has been a bottom-25 unit in total defense this season, allowing 414.3 total yards per game, which ranks 25th-worst. Offensively, they rank 33rd with 421.4 total yards per contest.
• Duke's defense ranks 97th in the FBS with 29.4 points allowed per contest, but it has been led by its offense, which ranks 19th-best by compiling 34.6 points per game.