Villanova vs. DePaul Dunkel Predictions & Vegas Odds - Dec. 31

The Villanova Wildcats (10-2, 1-0 Big East) host the DePaul Blue Demons (8-5, 0-2 Big East) at The William B. Finneran Pavilion, beginning at 6 p.m. ET on Wednesday, December 31, 2025. The Wildcats are 12.5-point favorites in the game. The matchup has an over/under of 139 points.

Villanova took care of business in its most recent game 64-56 against Seton Hall on Tuesday. Acaden Lewis recorded 16 points, five rebounds and two assists for Villanova. DePaul is coming off of a 72-54 loss to UConn in its last game on Sunday. Layden Blocker scored a team-leading 11 points for DePaul in the loss.

Villanova vs. DePaul Odds and Game Time

• When: Wednesday, December 31, 2025 at 6 p.m. ET
• Where: The William B. Finneran Pavilion in Bryn Mawr, Pennsylvania
• Spread favorite: Villanova -12.5
• Moneyline favorite: Villanova -952
• Moneyline underdog: DePaul +622
• Over/Under: 139 points

How to watch Villanova vs. DePaul

• TV Channel: FOX Sports 1
• Live Stream: Fubo
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Villanova vs. DePaul

• Eight of Villanova's games this season have gone over Wednesday's over/under of 139 points.
• In DePaul's 13 games this season, eight finished with more combined points than Wednesday's point total of 139.
• The total for the matchup of 139 is 14.4 points fewer than the combined points per game averages for the Wildcats (78.7 points per game) and the Blue Demons (74.7 points per game).
• This game's over/under is 3.1 fewer points than the 135.9 these two teams combine to give up per game in 2024.
• This season, the average over/under for Villanova's games is 145.6 points, 6.6 more than the total of 139 points set for this contest.
• The over/under for this game is 4.7 points lower than the average over/under in DePaul's games this season (143.7 points).

Betting the Spread: Villanova vs. DePaul

• Villanova has nine wins against the spread in 12 games this season.
• The Wildcats have been favored by 12.5 points or more six times this season and are 5-1 ATS in those contests.
• DePaul has played 13 games, with seven wins against the spread.
• The Blue Demons have been underdogs by 12.5 points or more two times this season and covered the spread once.
• Villanova is 4-2 against the spread, and 6-0 overall, at home.
• At home, Villanova is 3-1 ATS as a 12.5-point favorite or more.

Betting the Moneyline: Villanova vs. DePaul

• This season, Villanova has been listed as the moneyline favorite in eight games and won them all.
• The Wildcats are undefeated in five games this season when favored by -952 or more on the moneyline.
• The implied probability of a win from Villanova, based on the moneyline, is 90.5%.
• DePaul has been a moneyline underdog in five games this season and has come away with the win one time (20%) in those contests.
• The Blue Demons have been listed as an underdog of +622 or more on two occasions this season and lost both games.
• The moneyline set for this matchup implies DePaul has a 13.9% chance of coming away with a victory in the contest.

Dunkel Index Prediction for Villanova vs. DePaul

• Pick ATS: Villanova (- 12.5)
• Pick OU: Under (139)
  
• Prediction: Villanova 75 - DePaul 53