Vanderbilt vs. Iowa Dunkel NCAA Football Picks, Predictions and Odds - ReliaQuest Bowl

The Vanderbilt Commodores are 5.5-point favorites as they hit the field against the Iowa Hawkeyes in the ReliaQuest Bowl on December 31, 2025 at 12 p.m. ET on ESPN.

In their most recent action, the Commodores won against the Tennessee Volunteers, 45-24.

Against the Nebraska Cornhuskers in their last game, the Hawkeyes won 40-16.

Vanderbilt vs. Iowa Predictions

Ahead of the upcoming game between the Vanderbilt Commodores and Iowa Hawkeyes, computer-derived against-the-spread, over/under, and score predictions are below, based on data from Dunkel Index.

• Pick ATS: Hawkeyes (+ 5.5)
• Pick OU: Under (45.5)
  
• Prediction: Commodores 21 - Hawkeyes 20

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Vanderbilt vs. Iowa Moneylines

Grab a peek below at the latest moneylines for the Commodores-Hawkeyes matchup.

• Vanderbilt Moneyline: -205
• Iowa Moneyline: +169

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Vanderbilt Betting Insights

• Vanderbilt has won all six of the games it has been favored on the moneyline this season.
• Vanderbilt has played four times as a moneyline favorite with odds of -205 or shorter, and claimed a victory in each game.
• In nine games this season, the Commodores and their opponents have scored more than 45.5 combined points.
• Commodores matchups this year have an average total of 52.3, 6.8 more points than this game's over/under.
• The Commodores are the 12th-highest scoring team in college football this year. The Hawkeyes have scored the 69th-most points.

Iowa Betting Insights

• Iowa has been listed as the underdog four times this season and has failed to win any of those games.
• This season, Iowa has been at least a +169 underdog on the moneyline two times, losing each of those contests.
• Iowa has combined with its opponent to score more than 45.5 points in five of 12 games this season.
• Iowa has a 43.4-point average over/under in their outings this season, 2.1 fewer points than this game's point total.

Watch Vanderbilt vs. Iowa on Fubo.

Key Stats for Vanderbilt vs. Iowa

• The Commodores sport the 55th-ranked defense this season (355.8 yards allowed per game), and they've been better offensively, ranking 10th-best with 468.5 yards per game.
• On offense, Vanderbilt has been a top-25 unit, ranking eighth-best in the FBS by totaling 39.4 points per game. The Commodores rank 43rd on defense (21.9 points allowed per game).
• The Hawkeyes rank 16th-worst in total yards per game on offense (315.2), but at least they've been dominating on the other side of the ball, ranking sixth-best in total yards surrendered per game (270.6).
• Iowa ranks 58th in the FBS with 28.9 points per contest, but it has been led by its defense, which ranks sixth-best by allowing just 15.2 points per contest.