USC vs. UCLA Dunkel NCAA Football Picks, Predictions and Odds - Nov. 29

The No. 19 USC Trojans (8-3) are 21.5-point favorites when they host the UCLA Bruins (3-8) in a Big Ten matchup on Saturday, November 29, 2025 at Los Angeles Memorial Coliseum.

Last time around, the Trojans fell to the Oregon Ducks, with 42-27 being the final score.

In their last contest, the Bruins lost versus the Washington Huskies, 48-14.

USC vs. UCLA Predictions

For the upcoming game between the USC Trojans and UCLA Bruins, computer-calculated against-the-spread, over/under, and score predictions are below, based on data from Dunkel Index.

• Pick ATS: Trojans (- 21.5)
• Pick OU: Over (58.5)
  
• Prediction: Trojans 48 - Bruins 19

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USC vs. UCLA Moneylines

Grab a peek below at the most recent moneylines for the Trojans-Bruins matchup.

• USC Moneyline: -1887
• UCLA Moneyline: +970

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USC Betting Insights

• USC has put together an 8-1 record in games it was favored on the moneyline (winning 88.9% of those games).
• USC has played as a moneyline favorite of -1887 or shorter in only two games this season, and it won both.
• In five of 11 games this season, the Trojans and their opponents have combined to total more than 58.5 points.
• The average total in Trojans games this season is 57.8, 0.7 points fewer than this matchup's over/under.
• The Trojans are the 16th-highest scoring team in college football this year. The Bruins have scored the 125th-most points.

UCLA Betting Insights

• UCLA has entered the game as an underdog seven times this season and won twice.
• This season, UCLA has won one of its three games when it is the underdog by at least +970 on the moneyline.
• UCLA has combined with its opponents to score more than 58.5 points in three of 11 games this season.
• UCLA's games this season have had an average of 50.2 points, 8.3 fewer points than this game's total.

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Key Stats for USC vs. UCLA

• The last four times UCLA and USC have matched up, the two teams share a split 2-2 record.
• In their most recent four head-to-head meetings, each team has covered two times with those games hitting the over on the point total on two occasions.
• Offensively, the Trojans have been a top-25 unit, ranking seventh-best in the FBS by putting up 479.2 yards per game. They rank 52nd on defense (352.5 yards allowed per game).
• On the offensive side of the ball, USC has been a top-25 unit, ranking 13th-best in the FBS by totaling 37.2 points per game. The Trojans rank 58th on defense (23.5 points allowed per game).
• The Bruins rank 20th-worst in total yards per game (320.9), but they've been better defensively, ranking 80th in the FBS with 386.9 total yards ceded per contest.
• UCLA has struggled on both offense and defense this season, ranking 14th-worst in points (18.9 per game) and 12th-worst in points surrendered (33.8 per game).