South Florida vs. Old Dominion Dunkel NCAA Football Picks, Predictions and Odds - Cure Bowl

The Cure Bowl features a battle between the South Florida Bulls (who are 3-point favorites) and the Old Dominion Monarchs on December 17, 2025 at 5 p.m. ET on ESPN.

The Bulls won versus the Rice Owls in their most recent game, 52-3.

The Monarchs won versus the Georgia State Panthers in their last game, 27-10.

South Florida vs. Old Dominion Predictions

For the upcoming game between the South Florida Bulls and Old Dominion Monarchs, computer-derived against-the-spread, over/under, and score predictions are below, per Dunkel Index.

• Pick ATS: Monarchs (+ 3)
• Pick OU: Over (53.5)
  
• Prediction: Bulls 29 - Monarchs 28

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South Florida vs. Old Dominion Moneylines

Take a peek below at the most recent moneylines for the Bulls-Monarchs matchup.

• South Florida Moneyline: -152
• Old Dominion Moneyline: +127

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South Florida Betting Insights

• South Florida has a 6-2 record in games it was favored on the moneyline (winning 75% of those games).
• In games it has played as a moneyline favorite with odds of -152 or shorter, South Florida has a record of 6-2 (75%).
• The Bulls 12 games this season have gone over this contest's total of 53.5 points 10 times.
• Bulls contests this year have an average total of 61.9, 8.4 more points than this game's over/under.
• The Bulls are the fourth-highest scoring team in college football this year. The Monarchs have scored the 34th-most points.

Old Dominion Betting Insights

• Old Dominion has been an underdog in three games this season and won one (33.3%) of those contests.
• Old Dominion has entered two games this season as the underdog by +127 or more and is 1-1 in those contests.
• Old Dominion has played six games this season that have gone over 53.5 combined points scored.
• Old Dominion's games this year have had a 54.8-point total on average, 1.3 more points than this matchup's over/under.

Watch South Florida vs. Old Dominion on Fubo.

Key Stats for South Florida vs. Old Dominion

• The Bulls rank 81st in total defense this season (385.2 yards allowed per game), but they've been playing really well on the other side of the ball, ranking second-best in the FBS with 501.7 total yards per game.
• South Florida ranks 55th in scoring defense this year (23.3 points allowed per game), but has been thriving on the other side of the ball, ranking second-best in the FBS with 43 points per game.
• The Monarchs' defense ranks 32nd in the FBS with 331.4 total yards allowed per contest, but they've been bolstered by their offense, which ranks 15th-best by racking up 460.8 total yards per game.
• Old Dominion's defense has been leading the way for the team, as it ranks 21st-best in the FBS with 19.3 points allowed per contest. In terms of offense, it is putting up 32.7 points per game, which ranks 29th.