Mariners vs. Astros Dunkel MLB Picks, Predictions and Prop Bets - Sept. 23

Dominic Canzone carries an 11-game hitting streak into the Seattle Mariners' game against the Houston Astros at 10:10 p.m. ET on Wednesday, at T-Mobile Park. George Kirby (9-11, 4.24 ERA) gets the start for the Mariners, who are 73-84 this season and third in the AL West. Ethan Pecko (1-0, 3.77 ERA) is starting for the Astros, who are 78-79 and first in the AL West.

Oddsmakers have made the Mariners a decent moneyline favorite (-129) at home over the Astros (+106). The game's over/under is set at 7.5.

Mariners vs. Astros Odds, Game Time

• Game day: Wednesday, September 23, 2026
• Game time: 10:10 p.m. ET
• Location: Seattle, Washington
• Stadium: T-Mobile Park
• Favorite: Mariners (-129)
• Underdog: Astros (+106)
• Over/under: 7.5

How to Watch Mariners vs. Astros

• TV Channel: ESPN
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Mariners vs. Astros: Betting the Moneyline

• The Mariners have compiled a 60-61 record in games they were listed as the moneyline favorite (winning 49.6% of those games).
• Houston has come away with 44 wins in the 87 contests it has been listed as the underdogs in this season.
• Seattle has a record of 47-38 in games when oddsmakers favor them by at least -129 on the moneyline.
• The Astros have a mark of 28-27 in contests where bookmakers favor them by +106 or worse on the moneyline.
• Based on this matchup's moneyline, the Mariners have an implied win probability of 56.3%.
• The Astros have an implied victory probability of 48.5% according to the moneyline set for this matchup.

Mariners vs. Astros: Betting the Spread & Total

• The Mariners have combined with opponents to go over the total 80 times this season for an 80-68-9 record against the over/under.
• Houston and its opponents have gone over the total this season in 75 of its 157 opportunities.
• The Mariners have a 58-99-0 record against the spread this season.
• In 157 games with a line this season, the Astros have a mark of 81-76-0 against the spread.