Mariners vs. Astros Dunkel MLB Picks, Predictions and Prop Bets - Sept. 22

Yordan Alvarez is only one RBI away from his 100th of the campaign as his Houston Astros face the Seattle Mariners on Tuesday at 9:40 p.m. ET. Logan Gilbert (12-10, 3.69 ERA) will start for the Mariners, who are 73-83 this season and third in the AL West. Cristian Javier (2-6, 5.31 ERA) is expected to start for the Astros, who are 77-79 and second in the AL West.

With the Astros (+116) visiting, the Mariners (-140) are a solid favorite on the moneyline. The game's over/under is 7.5.

Mariners vs. Astros Odds, Game Time

• Game day: Tuesday, September 22, 2026
• Game time: 9:40 p.m. ET
• Location: Seattle, Washington
• Stadium: T-Mobile Park
• Favorite: Mariners (-140)
• Underdog: Astros (+116)
• Over/under: 7.5

How to Watch Mariners vs. Astros

• TV Channel: SEAM and SCHN
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Mariners vs. Astros: Betting the Moneyline

• The Mariners have gone 60-60 in games they were listed as the moneyline favorite (winning 50% of those games).
• Houston has come away with 43 wins in the 86 contests it has been listed as the underdogs in this season.
• Seattle has entered 58 games this season favored by -140 or more and is 35-23 in those contests.
• This year, the Astros have won 17 of 36 games when listed as at least +116 or worse on the moneyline.
• The Mariners have an implied moneyline win probability of 58.3% in this matchup.
• Bookmakers have implied with the moneyline set for this matchup that the Astros have a 46.3% chance of pulling out a win.

Mariners vs. Astros: Betting the Spread & Total

• The Mariners have had an over/under set by oddsmakers 156 times, and have combined with opponents to go over the total in 80 of those games (80-67-9).
• So far this season, Houston and its opponents have hit the over in 75 of its 156 games with a total.
• The Mariners have a 58-98-0 record against the spread this season (covering just 37.2% of the time).
• The Astros are 80-76-0 against the spread in their 156 games that had a posted line this season.