Santa Clara vs. Louisiana Dunkel Predictions & Vegas Odds - Nov. 21

The Santa Clara Broncos (5-0) host the Louisiana Ragin' Cajuns (1-4) at Leavey Center, beginning at 10 p.m. ET on Friday, November 21, 2025. The Ragin' Cajuns are 19.5-point underdogs in the game. The matchup's over/under is set at 139.5.

In its last game on Tuesday, Santa Clara secured a 64-55 win over Idaho State. In the victory, Christian Hammond led Santa Clara with 16 points. Louisiana's last contest on Tuesday ended in a 93-66 loss to Stanford. Joshua Lewis scored 16 points in Louisiana's loss, leading the team.

Santa Clara vs. Louisiana Odds and Game Time

• When: Friday, November 21, 2025 at 10 p.m. ET
• Where: Leavey Center in Santa Clara, California
• Spread favorite: Santa Clara -19.5
• Moneyline favorite: Santa Clara -3846
• Moneyline underdog: Louisiana +1413
• Over/Under: 139.5 points

How to watch Santa Clara vs. Louisiana

• TV Channel: ESPN+
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Santa Clara vs. Louisiana

• Santa Clara and its opponents have hit the over on this game's total (139.5 points) three times this season.
• There have been two games featuring Louisiana this season with more combined points than Friday's point total of 139.5.
• The point total for the game of 139.5 is 5.1 points fewer than the combined points per game averages for the Broncos (82.2) and Ragin' Cajuns (62.4).
• The 140 points per game these two teams allow to opponents combined this season are 0.5 more than the 139.5-point over/under in this contest.
• This season, the average over/under for Santa Clara's games is 147.4 points, 7.9 more than the total of 139.5 points set for this contest.
• A difference of 2.3 points separates this matchup's over/under (139.5 points) and the average over/under in Louisiana's games (137.2) this season.

Betting the Spread: Santa Clara vs. Louisiana

• Santa Clara has three wins against the spread in four games this year.
• Louisiana has two wins against the spread in five games this season.
• This season, the Ragin' Cajuns are winless ATS when entering a game as an underdog of 19.5 points or more.
• At home this season, Santa Clara has two wins against the spread and is 3-0 overall.
• Louisiana is 0-3 overall, and winless against the spread, away from home.

Betting the Moneyline: Santa Clara vs. Louisiana

• Santa Clara has been listed as the moneyline favorite three times this season and has won all of those games.
• The Broncos have not entered a game this season with shorter moneyline odds than -3846.
• The moneyline for this contest implies a 97.5% chance of a victory for Santa Clara.
• Louisiana has been named as the moneyline underdog four times this season but has yet to come away with a victory in any of those games.
• The Ragin' Cajuns have played as an underdog of +1413 or more just one time this year and came away with a loss in that game.
• Louisiana has an implied victory probability of 6.6% according to the moneyline set by oddsmakers for this matchup.