San Francisco vs. Loyola Chicago Dunkel Predictions & Vegas Odds - Dec. 17

The San Francisco Dons (6-5) hit the court against the Loyola Chicago Ramblers (3-8) as 12.5-point favorites on Wednesday, December 17, 2025 at 10 p.m. ET on ESPN+. The matchup's point total is set at 142.5.

Last time out, San Francisco lost 85-75 to Saint Louis on Saturday. Ryan Beasley scored a team-leading 21 points for San Francisco in the loss. Loyola Chicago lost its last game 84-75 against Chicago State on Sunday. Xavier Amos scored a team-high 18 points for Loyola Chicago in the loss.

San Francisco vs. Loyola Chicago Odds and Game Time

• When: Wednesday, December 17, 2025 at 10 p.m. ET
• Where: Chase Center in San Francisco, California
• Spread favorite: San Francisco -12.5
• Moneyline favorite: San Francisco -775
• Moneyline underdog: Loyola Chicago +560
• Over/Under: 142.5 points

How to watch San Francisco vs. Loyola Chicago

• TV Channel: ESPN+
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: San Francisco vs. Loyola Chicago

• This season, six of San Francisco's 10 games have gone over Wednesday's total of 142.5 points.
• In Loyola Chicago's 11 games this season, five finished with more combined points than Wednesday's total of 142.5.
• The Dons average 74.6 points per game against the Ramblers' 68.3, amounting to 0.4 points over the contest's over/under of 142.5.
• These two teams give up a combined 145.4 points per game, 2.9 more than this contest's over/under.
• San Francisco has seen a 144.1 average over/under in its games this season, 1.6 points more than the over/under in this contest.
• Loyola Chicago's games have an average over/under of 144.2 points this season, 1.7 more points than the over/under for this matchup.

Betting the Spread: San Francisco vs. Loyola Chicago

• In San Francisco's 10 games this year, it has five wins against the spread.
• This season, the Dons have just one ATS win in three games as a favorite of 12.5 points or more.
• Loyola Chicago has covered the spread once this year.
• San Francisco has covered the spread twice at home, and is 3-1 overall there, this year.
• At home, as a 12.5-point favorite or more, San Francisco has one win ATS (1-2).

Betting the Moneyline: San Francisco vs. Loyola Chicago

• This season, San Francisco has won three out of the six games in which it has been the moneyline favorite.
• The Dons have a record of 2-1 in games where sportsbooks favor them by at least -775 on the moneyline.
• The oddsmakers' moneyline implies a 88.6% chance of a victory for San Francisco.
• Loyola Chicago has been posted as the moneyline underdog four times this season but has yet walk away from any of those games with an upset.
• Oddsmakers have given the Ramblers the worst odds of winning they have seen this season with a +560 moneyline listed for this contest.
• The moneyline set for this matchup implies Loyola Chicago has a 15.2% chance of walking away with the win.