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Giants vs. Cardinals Dunkel MLB Picks, Predictions and Prop Bets - Sept. 23

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23 September 2025 By Data Skrive

The St. Louis Cardinals will look to Ivan Herrera, riding a two-game homer streak, versus the San Francisco Giants at 9:45 p.m. ET on Tuesday, at Oracle Park. Logan Webb (14-11, 3.27 ERA) gets the start for the Giants, who are 77-80 this season and fourth in the NL West. Andre Pallante (6-15, 5.29 ERA) is expected to start for the Cardinals, who are 77-80 and fourth in the NL Central.

The Giants (-202) are moneyline favorites at home over the Cardinals (+167). The over/under for the Giants-Cardinals game is set at 7.5.

Giants vs. Cardinals Odds, Game Time

Game day: Tuesday, September 23, 2025
Game time: 9:45 p.m. ET
Location: San Francisco, California
Stadium: Oracle Park
Favorite: Giants (-202)
Underdog: Cardinals (+167)
Over/under: 7.5

How to Watch Giants vs. Cardinals

TV Channel: MLB.TV - San Francisco Giants
Live Stream: Fubo (Watch for free)

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Giants vs. Cardinals: Betting the Moneyline

The Giants have put together a 46-42 record in games they were listed as the moneyline favorite (winning 52.3% of those games).
St. Louis has won in 43, or 48.3%, of the 89 contests it has been named as odds-on underdogs in this year.
San Francisco has entered 10 games this season favored by -202 or more and is 5-5 in those contests.
The Cardinals have a mark of 1-7 in contests where bookmakers favor them by +167 or worse on the moneyline.
Based on this matchup's moneyline, the Giants have an implied win probability of 66.9%.
The moneyline set for this matchup implies the Cardinals have a 37.5% chance of coming away with a victory in the contest.

Giants vs. Cardinals: Betting the Spread & Total

The Giants have played in 157 games with a set over/under, and have combined with their opponents to go over the total 73 times (73-74-10).
So far this season, St. Louis and its opponents have hit the over in 78 of its 156 games with a total.
The Giants have covered 46.5% of their games this season, going 73-84-0 ATS.
In 156 games with a line this season, the Cardinals have a mark of 80-76-0 against the spread.

Dunkel Index Prediction for Giants vs. Cardinals

Pick OU: Over (7.5)
Prediction: Giants 5 - Cardinals 4

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About the author

Data Skrive

Data Skrive creates sports articles about every player, on every team, in every league, for every game, for every fan. Data Skrive know sports. With over 100M monthly readers across 500+ websites and 200+ DMAs, their innovative Fan Engagement Solution creates engaging and entertaining sports content that fans value to drive revenue for their customers. Sports never stop, and covering every topic at the right time is not feasible. Data Skrive's technology is able to cover highly relevant topics that are interesting and engaging to your fans.