Saint Louis vs. Santa Clara Dunkel Predictions & Vegas Odds - Nov. 27

The Saint Louis Billikens (5-0) visit the Santa Clara Broncos (6-0) at Acrisure Arena, starting at 7 p.m. ET on Thursday, November 27, 2025. The Billikens are 1.5-point favorites in the game. The over/under for the matchup is set at 159.5.

In its last time out, Saint Louis won on Friday 91-60 against Purdue Fort Wayne. In the win, Dion Brown led Saint Louis with 21 points. Santa Clara is coming off of an 80-43 victory against Louisiana in its most recent game on Friday. Christian Hammond scored a team-leading 19 points for Santa Clara in the victory.

Saint Louis vs. Santa Clara Odds and Game Time

• When: Thursday, November 27, 2025 at 7 p.m. ET
• Where: Acrisure Arena in Palm Desert, California
• Spread favorite: Saint Louis -1.5
• Moneyline favorite: Saint Louis -132
• Moneyline underdog: Santa Clara +111
• Over/Under: 159.5 points

How to watch Saint Louis vs. Santa Clara

• TV Channel: CBS Sports Network
• Live Stream: Fubo
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Saint Louis vs. Santa Clara

• Saint Louis and its opponents have combined to score more than 159.5 points in a game twice this season.
• This season, Santa Clara has played just one game with a combined score higher than 159.5 points.
• The total for the contest of 159.5 is 17.9 points fewer than the combined points per game averages for the Billikens (95.6) and Broncos (81.8).
• The 130.1 points per game these two teams surrender to opponents on average this season are 29.4 fewer than the 159.5 over/under in this contest.
• On average, Saint Louis has seen a 164.2-point over/under in its games this season, 4.7 more points than the over/under in this matchup.
• Santa Clara's games have an average over/under of 143.3 points this season, 16.2 points lower than the over/under for this game.

Betting the Spread: Saint Louis vs. Santa Clara

• Saint Louis has played five games, with four wins against the spread.
• The Billikens are 4-1 ATS when favored by 1.5 points or more this season.
• Santa Clara has four wins against the spread in five games this season.
• The Broncos covered the spread in their only game when underdogs by 1.5 points or more.
• Santa Clara is 4-0 overall, and 3-1 against the spread, at home.
• As a 1.5-point underdog or greater at home, Santa Clara is 3-1 ATS.

Betting the Moneyline: Saint Louis vs. Santa Clara

• Saint Louis has been listed as the moneyline favorite five times this season and has won all of those games.
• The Billikens have entered five games this season favored by -132 or more, and won each of those games.
• The oddsmakers' moneyline implies a 56.9% chance of a victory for Saint Louis.
• Santa Clara came away victorious in the one game it played as the moneyline underdog this season.
• The Broncos have played as an underdog of +111 or more just one time this year and came away with a win in that game.
• Santa Clara has an implied victory probability of 47.4% according to the moneyline set by oddsmakers for this matchup.