Pirates vs. Cardinals Dunkel MLB Picks, Predictions and Prop Bets - Sept. 23

The Pittsburgh Pirates will aim to keep a five-game win streak alive when they host the St. Louis Cardinals at 6:40 p.m. ET on Wednesday. Lake Bachar (1-4, 3.56 ERA) will start for the Pirates, who are 80-77 this season and third in the NL Central. Matthew Liberatore (5-14, 5.36 ERA) is expected to start for the Cardinals, who are 76-81 and fourth in the NL Central.

The Pirates are moderate favorites on the moneyline (-138) at home over the Cardinals (+114). The game's total is 7.5.

Pirates vs. Cardinals Odds, Game Time

• Game day: Wednesday, September 23, 2026
• Game time: 6:40 p.m. ET
• Location: Pittsburgh, Pennsylvania
• Stadium: PNC Park
• Favorite: Pirates (-138)
• Underdog: Cardinals (+114)
• Over/under: 7.5

How to Watch Pirates vs. Cardinals

• TV Channel: SportsNet PT and CARD
• Live Stream: Fubo (Watch for free)

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Pirates vs. Cardinals: Betting the Moneyline

• The Pirates have won 59.3% of the games this season when they were the moneyline favorite (48-33).
• St. Louis has been underdogs in 104 games this season and has come away with the win 49 times (47.1%) in those contests.
• This season Pittsburgh has won 24 of its 43 games, or 55.8%, when favored by at least -138 on the moneyline.
• The Cardinals have a mark of 27-28 in contests where sportsbooks favor them by +114 or worse on the moneyline.
• The implied moneyline probablility for this matchup gives the Pirates a 58% chance to win.
• Sportsbooks have implied with the moneyline set for this matchup that the Cardinals have a 46.7% chance of pulling out a win.

Pirates vs. Cardinals: Betting the Spread & Total

• The Pirates have played in 157 games with over/under set, and have combined with opponents to go over the total 80 times (80-70-7).
• So far this season, St. Louis and its opponents have hit the over in 70 of its 157 games with a total.
• The Pirates have covered 49.7% of their games this season, going 78-79-0 ATS.
• The Cardinals have posted a record of 85-72-0 against the spread this season.