Pirates vs. Cardinals Dunkel MLB Picks, Predictions and Prop Bets - Sept. 22

Ivan Herrera leads the St. Louis Cardinals into a matchup against the Pittsburgh Pirates, after homering twice in a 5-3 victory over the Nationals, at 6:40 p.m. ET on Tuesday. Jared Jones (4-6, 4.17 ERA) gets the start for the Pirates, who are 79-77 this season and third in the NL Central. Andre Pallante (12-7, 3.70 ERA) is the expected starter for the Cardinals, who are 76-80 and fourth in the NL Central.

The Pirates (-174) are moneyline favorites at home over the Cardinals (+142). The game has an over/under set at 7.5 runs.

Pirates vs. Cardinals Odds, Game Time

• Game day: Tuesday, September 22, 2026
• Game time: 6:40 p.m. ET
• Location: Pittsburgh, Pennsylvania
• Stadium: PNC Park
• Favorite: Pirates (-174)
• Underdog: Cardinals (+142)
• Over/under: 7.5

How to Watch Pirates vs. Cardinals

• TV Channel: SportsNet PT and CARD
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Pirates vs. Cardinals: Betting the Moneyline

• The Pirates have been the moneyline favorite 80 total times this season. They've finished 47-33 in those games.
• St. Louis has come away with 49 wins in the 103 contests it has been listed as the underdogs in this season.
• Pittsburgh has a record of 8-7 in games when sportsbooks favor them by at least -174 on the moneyline.
• This year, the Cardinals have won eight of 21 games when listed as at least +142 or worse on the moneyline.
• Based on this contest's moneyline, the Pirates' implied win probability is 63.5%.
• The Cardinals have an implied victory probability of 41.3% according to the moneyline set for this matchup.

Pirates vs. Cardinals: Betting the Spread & Total

• In the 156 games in which bookmakers have set an over/under for the Pirates, they have combined with opponents to go over the total 80 times (80-69-7).
• Games involving St. Louis have gone over the total set by oddsmakers in 70 of 156 chances this season.
• The Pirates have a 77-79-0 record ATS this season (covering 49.4% of the time).
• The Cardinals have an against the spread mark of 85-71-0 in 156 games with a line this season.