Oregon vs. James Madison Dunkel NCAA Football Picks, Predictions and Odds - CFP First Round
15 December 2025

To begin this year's College Football Playoff, the Oregon Ducks (11-1) will host the James Madison Dukes (12-1) starting at 7:30 p.m. ET at Autzen Stadium in Eugene, Oregon. Oregon is favored by 20.5 points.
The Ducks won against the Washington Huskies in their most recent game, 26-14.
In their last game, the Dukes won against the Troy Trojans, 31-14.
Oregon vs. James Madison Predictions
Ahead of the upcoming contest between the Oregon Ducks and James Madison Dukes, computer-derived against-the-spread, over/under, and score predictions are below, based on data from Dunkel Index.
- Pick ATS: Ducks (- 20.5)
- Pick OU:
Under (45.5)
- Prediction: Ducks 35 - Dukes 9
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Oregon vs. James Madison Moneylines
Snag a look below at the most recent moneylines for the Ducks-Dukes matchup.
- Oregon Moneyline: -1961
- James Madison Moneyline: +1010
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Oregon Betting Insights
- Oregon has been the moneyline favorite 10 total times this season. It has finished 9-1 in those games.
- Oregon has played in five games as a moneyline favorite with odds of -1961 or shorter and won them all.
- The Ducks 12 games this season have gone over this contest's total of 45.5 points nine times.
- The average total in Ducks matchups this year is 52.3, 6.8 more points than this game's over/under.
- The Dukes are college football's eighth-highest scoring team this season compared to the 11th-ranked Ducks.
James Madison Betting Insights
- James Madison lost the only game it has played as the underdog this season.
- James Madison has not entered a game this season with longer moneyline odds than +1010.
- James Madison and its opponents have combined to score more than 45.5 points in six of 13 games this season.
- James Madison's games this year have had a 51.2-point total on average, 5.7 more points than this matchup's over/under.
Watch Oregon vs. James Madison on Fubo.
Key Stats for Oregon vs. James Madison
- The Ducks have been making things happen on both sides of the ball this year, as they rank 14th-best in total offense (465.2 yards per game) and fourth-best in total defense (251.6 yards allowed per game).
- Oregon has been clicking on all fronts this season, as they rank ninth-best in scoring offense (38.2 points per game) and seventh-best in scoring defense (14.8 points allowed per game).
- The Dukes have excelled on both sides of the ball this season, ranking 22nd-best in total offense (448.3 total yards per game) and second-best in total defense (247.6 total yards allowed per game).
- James Madison has been productive on both sides of the ball this season, ranking 10th-best in points per game (37.3) and 10th-best in points allowed per game (15.8).
