Missouri State vs. New Mexico State Dunkel NCAA Football Picks, Predictions and Odds - Oct. 22

CUSA rivals square off when the Missouri State Bears (3-3) visit the New Mexico State Aggies (3-3) on Wednesday, October 22, 2025 at Aggie Memorial Stadium. Missouri State is favored by 1.5 points.

The Bears won versus the Middle Tennessee Blue Raiders in their most recent game, 22-20.

In their last game, the Aggies lost against the Liberty Flames, 30-27.

Missouri State vs. New Mexico State Predictions

Ahead of the upcoming contest between the Missouri State Bears and New Mexico State Aggies, computer-calculated against-the-spread, over/under, and score predictions are below, per Dunkel Index.

• Pick ATS: Bears (- 1.5)
• Pick OU: Over (50.5)
  
• Prediction: Bears 31 - Aggies 26

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Missouri State vs. New Mexico State Moneylines

Take a peek below at the most up-to-date moneylines for the Bears-Aggies game.

• Missouri State Moneyline: -114
• New Mexico State Moneyline: -106

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Missouri State Betting Insights

• Missouri State has been the moneyline favorite just two other times so far this season, and they won both of the games.
• Missouri State has played as a moneyline favorite of -114 or shorter in just two games this season, and it won both.
• In two games this season, the Bears and their opponents have combined to total more than 50.5 points.
• The average total in Bears games this year is 56.3, 5.8 more than this matchup's over/under.
• The Bears are the 124th-highest scoring team in college football this year. The Aggies have scored the 117th-most points.

New Mexico State Betting Insights

• New Mexico State has won two of the five games it has played as an underdog this season.
• New Mexico State has entered five games this season as the underdog by -106 or more and is 2-3 in those contests.
• New Mexico State has played three games this season that have had more than 50.5 combined points scored.
• New Mexico State's games this season have had an average of 50.3 points, 0.2 fewer points than this game's total.

Watch Missouri State vs. New Mexico State on Fubo.

Key Stats for Missouri State vs. New Mexico State

• The Bears are totaling 367.5 yards per game on offense, which ranks them 84th in the FBS. Defensively, they rank 99th, allowing 394.8 yards per contest.
• Missouri State is averaging 21.7 points per game on offense (110th in the FBS), and ranks 107th on the other side of the ball with 29.7 points allowed per game.
• The Aggies' offense has been a bottom-25 unit in total offense this season, generating 324.3 total yards per game, which ranks 19th-worst in the FBS. On defense, they rank 86th with 381 total yards ceded per contest.
• From an offensive perspective, New Mexico State is compiling 23 points per contest (98th-ranked). It ranks 66th in the FBS on defense (24 points surrendered per game).