Iowa State vs. BYU Dunkel NCAA Football Picks, Predictions and Odds - Oct. 25

Oddsmakers project a competitive game when the Iowa State Cyclones (5-2) host the No. 11 BYU Cougars (7-0) on Saturday, October 25, 2025 in a matchup between Big 12 rivals at Jack Trice Stadium. Iowa State is favored by 2.5 points.

The Cyclones lost against the Colorado Buffaloes in their most recent game, 24-17.

Facing the Utah Utes in their last contest, the Cougars won 24-21.

Iowa State vs. BYU Predictions

For predictions on the upcoming game between the Iowa State Cyclones and BYU Cougars, computer-derived against-the-spread, over/under, and score predictions are below, per Dunkel Index.

• Pick ATS: Cyclones (- 2.5)
• Pick OU: Over (48.5)
  
• Prediction: Cyclones 29 - Cougars 24

Bet now on FanDuel Sportsbook!

Iowa State vs. BYU Moneylines

Snag a look below at the most recent moneylines for the Cyclones-Cougars game.

• Iowa State Moneyline: -136
• BYU Moneyline: +114

Pick with the best in the business! Get free picks for every game, every week at the Dunkel Index.

Iowa State Betting Insights

• Iowa State has won 80% of the games this season when it was the moneyline favorite (4-1).
• When it has played as a moneyline favorite with odds of -136 or shorter, Iowa State has a 4-1 record (winning 80% of its games).
• The Cyclones and their opponents have gone over 48.5 combined points in three of seven games this season.
• Cyclones outings this year have an average point total of 50.5, 2.0 more points than this game's over/under.
• The Cougars are college football's 29th-highest scoring team this season compared to the 64th-ranked Cyclones.

BYU Betting Insights

• BYU won the only game it has played as the underdog this season.
• BYU has played as an underdog of +114 or more once this season and won that game.
• BYU has combined with its opponents to score more than 48.5 points in three of seven games this season.
• BYU has a 50.0-point average over/under in their outings this season, 1.5 more points than this game's total.

Watch Iowa State vs. BYU on Fubo.

Key Stats for Iowa State vs. BYU

• The Cyclones rank 59th in total offense (405.3 yards per game) and 48th in total defense (345.3 yards allowed per game) this year.
• Iowa State is averaging 29.3 points per game on offense (66th in the FBS), and ranks 27th defensively with 19 points allowed per game.
• The Cougars' defense has been leading the way for the team, as they rank 18th-best in the FBS with 293 total yards allowed per contest. In terms of offense, they are accumulating 436.7 total yards per game, which ranks 34th.
• BYU has been thriving on the defensive side of the ball, surrendering only 15.6 points per game (14th-best). On offense, it ranks 30th by compiling 35.6 points per game.