Twins vs. Giants Dunkel MLB Picks, Predictions and Prop Bets - Sept. 21

The Minnesota Twins and San Francisco Giants square off on Monday at 9:45 p.m. ET, opening a three-game series at Oracle Park. Zebby Matthews (9-10, 4.74 ERA) gets the start for the Twins, who are 73-83 this season and third in the AL Central. Blade Tidwell (1-2, 4.56 ERA) is expected to start for the Giants, who are 64-92 and fourth in the NL West.

The Twins are currently a moderate moneyline favorite (-123) on the road at the Giants (+101). The game has an over/under of 8.5 runs.

Twins vs. Giants Odds, Game Time

• Game day: Monday, September 21, 2026
• Game time: 9:45 p.m. ET
• Location: San Francisco, California
• Stadium: Oracle Park
• Favorite: Twins (-123)
• Underdog: Giants (+101)
• Over/under: 8.5

How to Watch Twins vs. Giants

• TV Channel: NBCS-BA and MNNT
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Twins vs. Giants: Betting the Moneyline

• The Twins have won 32 of the 58 games they were the moneyline favorite this season (55.2%).
• San Francisco has been pegged as an underdog in 106 games this year and has walked away with the win 39 times (36.8%) in those games.
• This season Minnesota has won 16 of its 31 games, or 51.6%, when favored by at least -123 on the moneyline.
• This year, the Giants have won 34 of 91 games when listed as at least +101 or worse on the moneyline.
• Based on this contest's moneyline, the Twins' implied win probability is 55.2%.
• The moneyline set for this matchup implies the Giants have a 49.8% chance of walking away with the win.

Twins vs. Giants: Betting the Spread & Total

• The Twins have combined with opponents to go over the total 86 times this season for an 86-62-8 record against the over/under.
• San Francisco's games have gone over the total in 76 of its 155 chances.
• The Twins have gone 83-73-0 ATS this season.
• The Giants are 77-78-0 against the spread in their 155 games that had a posted line this season.