LSU vs. DePaul Dunkel Predictions & Vegas Odds - Nov. 29

The LSU Tigers (6-0) host the DePaul Blue Demons (5-2) at Raider Arena, beginning at 7 p.m. ET on Saturday, November 29, 2025. The Tigers are 5.5-point favorites in the game. The point total for the matchup is set at 152.5.

LSU is coming off of a 71-62 victory over Drake in its last outing on Friday. Dedan Thomas Jr. scored a team-leading 18 points for LSU in the victory. DePaul's most recent contest on Friday ended in a 75-61 victory over Georgia Tech. Layden Blocker scored 18 points in DePaul's victory, leading the team.

LSU vs. DePaul Odds and Game Time

• When: Saturday, November 29, 2025 at 7 p.m. ET
• Where: Raider Arena in Niceville, Florida
• Spread favorite: LSU -5.5
• Moneyline favorite: LSU -255
• Moneyline underdog: DePaul +208
• Over/Under: 152.5 points

How to watch LSU vs. DePaul

• TV Channel: CBS Sports Network
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: LSU vs. DePaul

• LSU and its opponents have combined to outscore Saturday's over/under (152.5 points) four times this season.
• There have been four DePaul games that finished with a combined score higher than 152.5 points this season.
• Together, the two teams combine for 173.9 points per game, 21.4 points more than the over/under of 152.5 for this contest.
• The 136.5 points per game these two teams allow their opponents to score on average this season are 16.0 fewer than the 152.5 over/under in this contest.
• On average, LSU has seen a 163.2-point over/under in its games this season, 10.7 more points than the over/under in this contest.
• DePaul's games have an average over/under of 147.1 points this season, 5.4 fewer points than the over/under for this game.

Betting the Spread: LSU vs. DePaul

• Against the spread, LSU is 3-3-0 this year.
• The Tigers have been favored by 5.5 points or more six times this season and are 3-3 ATS in those games.
• DePaul has four wins against the spread in seven games this year.
• This year, the Blue Demons won ATS in their only game as an underdog of 5.5 points or more.
• LSU is 3-2 against the spread, and 5-0 overall, at home this year.
• LSU is 3-2 ATS as a 5.5-point favorite or greater at home.

Betting the Moneyline: LSU vs. DePaul

• This season, LSU has been listed as the moneyline favorite in five games and won them all.
• The Tigers have been at least a -255 moneyline favorite five times this season and won each of those games.
• The bookmakers' moneyline implies a 71.8% chance of a victory for LSU.
• DePaul was defeated in the one game it played as the moneyline underdog this season.
• Oddsmakers have given the Blue Demons the worst odds of winning they have seen this season with a +208 moneyline listed for this contest.
• DePaul has an implied victory probability of 32.5% according to the moneyline set for this matchup.