Louisville vs. Creighton Dunkel Predictions & Vegas Odds - First Round

The No. 8 seed Louisville Cardinals (27-7) and the No. 9 seed Creighton Bluejays (24-10) will meet on Thursday at 12:15 p.m. ET in the opening round of the NCAA Tournament. Louisville is a 2.5-point favorite in the matchup, which airs on CBS. Here's everything you need to know ahead of this 8-9 matchup in the South Region bracket. The point total is set at 145.5 for the matchup.

In its last outing on Saturday, Louisville suffered a 73-62 loss to Duke. Terrence Edwards recorded 29 points, six rebounds and three assists for Louisville. Creighton fell in its last outing 82-66 against St. John's on Saturday. Ryan Kalkbrenner recorded 15 points, seven rebounds and one assist for Creighton.

Louisville vs. Creighton Odds and Game Time

• When: Thursday, March 20, 2025 at 12:15 p.m. ET
• Where: Rupp Arena in Lexington, Kentucky
• Spread favorite: Louisville -2.5
• Moneyline favorite: Louisville -141
• Moneyline underdog: Creighton +118
• Over/Under: 145.5 points

How to watch Louisville vs. Creighton

• TV Channel: CBS
• Live Stream: Fubo
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Louisville vs. Creighton

• This season, Louisville's games have seen a combined score higher than this matchup's 145.5-point over/under 21 times.
• There have been 17 Creighton games that ended with a combined score higher than 145.5 points this season.
• The over/under for the contest of 145.5 is 8.3 points fewer than the combined points per game averages for the Cardinals (78.6) and Bluejays (75.2).
• This matchup's over/under is 7.1 fewer points than the 138.4 these two teams combine to give up per game in 2023.
• On average, Louisville has had a 147.5-point over/under in its games this season, 2.0 more points than the over/under in this matchup.
• Creighton's games have an average over/under of 144.8 points this season, 0.7 fewer points than the over/under for this contest.

Betting the Spread: Louisville vs. Creighton

• Against the spread, Louisville is 20-14-0 this season.
• The Cardinals have been favored by 2.5 points or more 25 times this season and are 13-12 ATS in those matchups.
• In Creighton's 34 games this season, it has 20 wins against the spread.
• This season, the Bluejays have an against-the-spread record of 6-2 in their eight games as an underdog of 2.5 points or more.
• At home this year, Louisville is 14-3 overall and 8-9 against the spread.
• Louisville is 7-8 ATS as a 2.5-point favorite or more at home.
• On the road, Creighton is 9-2 against the spread, and 6-5 overall.
• This season Creighton is 4-1 ATS as 2.5-point underdogs or more away from home.

Betting the Moneyline: Louisville vs. Creighton

• This season, Louisville has been moneyline favorites 26 times and won 22, or 84.6%, of those games.
• The Cardinals have entered 25 games this season favored by -141 or more and are 21-4 in those contests.
• The oddsmakers' moneyline implies a 58.5% chance of a victory for Louisville.
• Creighton has been a moneyline underdog in 10 games this season and has come away with the win four times (40%) in those contests.
• The Bluejays have a mark of 3-5 in contests where sportsbooks give them odds of +118 or worse on the moneyline.
• The moneyline set for this matchup implies Creighton has a 45.9% chance of walking away with the win.