Iowa State vs. Oklahoma State Dunkel NCAA Football Picks, Predictions and Odds - Nov. 29

Oddsmakers heavily favor the Iowa State Cyclones (7-4) when they visit the Oklahoma State Cowboys (1-10) on Saturday, November 29, 2025 in a matchup between Big 12 rivals at Boone Pickens Stadium. Iowa State is favored by two touchdowns.

The Cyclones' most recent contest was versus the Kansas Jayhawks, and they won by a score of 38-14.

The Cowboys lost versus the UCF Knights in their last game, 17-14.

Iowa State vs. Oklahoma State Predictions

For insights on the upcoming game between the Iowa State Cyclones and Oklahoma State Cowboys, computer-calculated against-the-spread, over/under, and score predictions are below, based on data from Dunkel Index.

• Pick ATS: Cyclones (- 14)
• Pick OU: Over (46.5)
  
• Prediction: Cyclones 39 - Cowboys 15

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Iowa State vs. Oklahoma State Moneylines

Snag a peek below at the most up-to-date moneylines for the Cyclones-Cowboys matchup.

• Iowa State Moneyline: -621
• Oklahoma State Moneyline: +454

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Iowa State Betting Insights

• Iowa State has put together a 5-3 record in games it was listed as the moneyline favorite (winning 62.5% of those games).
• Iowa State has played as a moneyline favorite of -621 or shorter in just two games this season, and it won both.
• In five games this season, the Cyclones and their opponents have scored more than 46.5 total points.
• The average point total in Cyclones games this year is 51.3, 4.8 more than this matchup's over/under.
• The Cyclones are the 65th-highest scoring team in college football this year. The Cowboys have scored the 134th-most points.

Oklahoma State Betting Insights

• Oklahoma State has been the underdog in eight games this season, and it has failed to win any of those contests.
• Oklahoma State has not won as an underdog of +454 or more on the moneyline this season in seven such games.
• Oklahoma State and its opponents have combined to score more than 46.5 points in six of 11 games this season.
• Oklahoma State's contests this season have a 54.2-point average over/under, 7.7 more points than this game's total.

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Key Stats for Iowa State vs. Oklahoma State

• Over their last three meetings, Iowa State has put up two wins versus Oklahoma State.
• In those matchups against Iowa State, the Cowboys have covered two times while outscoring the total on one occasion.
• The Cyclones are averaging 400.2 yards per game on offense (59th in the FBS), and they rank 65th on defense with 368.1 yards allowed per game.
• Iowa State ranks 65th in scoring offense (28.1 points per game) and 33rd in scoring defense (20.8 points allowed per game) this year.
• The Cowboys have been outplayed on both offense and defense this season, ranking seventh-worst in total offense (298.2 total yards per game) and 19th-worst in total defense (424.9 total yards allowed per game).
• Oklahoma State has lots of room to improve, as it ranks third-worst in points per game (14.3) this season and 10th-worst in points allowed per game (34.5).