Iowa vs. Nebraska Dunkel NCAA Football Picks, Predictions and Odds - Nov. 28

A pair of the nation's top pass defenses meet when the Iowa Hawkeyes (7-4) take college football's 11th-ranked pass defense into a matchup with the Nebraska Cornhuskers (7-4), who have the No. 2 passing defense, on Friday, November 28, 2025. The Hawkeyes are 6.5-point favorites.

In their last action, the Hawkeyes won against the Michigan State Spartans, 20-17.

In their most recent game, the Cornhuskers lost against the Penn State Nittany Lions, 37-10.

Iowa vs. Nebraska Predictions

For the upcoming game between the Iowa Hawkeyes and Nebraska Cornhuskers, computer-calculated against-the-spread, over/under, and score predictions are below, based on data from Dunkel Index.

• Pick ATS: Cornhuskers (+ 6.5)
• Pick OU: Under (38.5)
  
• Prediction: Cornhuskers 17 - Hawkeyes 16

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Iowa vs. Nebraska Moneylines

Take a peek below at the most recent moneylines for the Hawkeyes-Cornhuskers game.

• Iowa Moneyline: -238
• Nebraska Moneyline: +194

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Iowa Betting Insights

• Iowa has won all six of the games it has been listed as the moneyline favorite this season.
• Iowa has played three times as a moneyline favorite with odds of -238 or shorter, and claimed a victory in each game.
• The Hawkeyes and their opponents have combined to score more than 38.5 points in six of 11 games this season.
• Hawkeyes contests this year have an average point total of 43.7, 5.2 more points than this game's over/under.
• The Hawkeyes score the 69th-most points in college football this season, while the Cornhuskers' offense puts up the 46th-most.

Nebraska Betting Insights

• Nebraska has entered the game as an underdog four times this season and won once.
• Nebraska has played as an underdog of +194 or more once this season and lost that game.
• Nebraska has combined with its opponent to score more than 38.5 points in eight of 11 games this season.
• Nebraska has a 49.3-point average over/under in their matchups this season, 10.8 more points than this game's total.

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Key Stats for Iowa vs. Nebraska

• Over their last four meetings, Iowa has tallied three wins versus Nebraska.
• The last four times the Hawkeyes have squared off with the Cornhuskers, they have posted a 2-1-1 record against the spread. The scoring has gone over the point total on two occasions.
• The Hawkeyes have the eighth-best defense this season in terms of total yards (267.9 yards allowed per game), but they rank 15th-worst on the offensive side of the ball (309.4 yards per game).
• Iowa owns the 69th-ranked offense this season (27.9 points per game), and has been better on the other side of the ball, ranking ninth-best with only 15.1 points allowed per game.
• The Cornhuskers' defensive unit has been leading the way for the team, as they rank 20th-best in the FBS with 307.5 total yards ceded per game. In terms of offense, they are putting up 379.6 total yards per game, which ranks 75th.
• With 30.5 points per game on the offensive side of the ball, Nebraska ranks 47th in the FBS. Defensively, it ranks 38th, surrendering 21.5 points per contest.