Illinois vs. Northwestern Dunkel NCAA Football Picks, Predictions and Odds - Nov. 29

The Land of Lincoln Trophy is up for grabs when the Illinois Fighting Illini (7-4) and the Northwestern Wildcats (6-5) clash on Saturday, November 29, 2025 at Memorial Stadium (Champaign, IL). The Fighting Illini are 7.5-point favorites.

The Fighting Illini lost versus the Wisconsin Badgers in their most recent game, 27-10.

The Wildcats' last game was versus the Minnesota Golden Gophers, and they won by a score of 38-35.

Illinois vs. Northwestern Predictions

For predictions on the upcoming contest between the Illinois Fighting Illini and Northwestern Wildcats, computer-calculated against-the-spread, over/under, and score predictions are below, sourced from Dunkel Index.

• Pick ATS: Wildcats (+ 7.5)
• Pick OU: Over (44.5)
  
• Prediction: Wildcats 26 - Fighting Illini 25

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Illinois vs. Northwestern Moneylines

Snag a look below at the most recent moneylines for the Fighting Illini-Wildcats game.

• Illinois Moneyline: -285
• Northwestern Moneyline: +231

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Illinois Betting Insights

• Illinois is 5-1 in games it was listed as the moneyline favorite (winning 83.3% of those games).
• When playing as a moneyline favorite with odds of -285 or shorter, Illinois has gone 4-1 (80%).
• Fighting Illini games this season have featured more combined points than this contest's total of 44.5 points eight times.
• The average total in Fighting Illini outings this year is 54.0, 9.5 more points than this game's over/under.
• The Fighting Illini score the 47th-most points in college football this season, while the Wildcats' offense racks up the 102nd-most.

Northwestern Betting Insights

• Northwestern has entered the game as an underdog six times this season and won once.
• Northwestern has a record of 1-3 when it is set as an underdog of +231 or more by bookmakers this season.
• Northwestern has played seven games this season that finished with a combined score over 44.5 points.
• The average over/under for Northwestern's contests this season is 46.1, 1.6 more points than this game's total.

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Key Stats for Illinois vs. Northwestern

• Illinois owns a 3-1 record against Northwestern in their last four matchups.
• The last four times the Fighting Illini have gone up against the Wildcats, they have a 3-1 record against the spread. The scoring went over the point total each time.
• Offensively, the Fighting Illini rank 80th in the FBS with 378.1 yards per game. Meanwhile, they rank 60th in total defense (359.5 yards allowed per contest).
• On offense, Illinois ranks 48th in the FBS with 30.2 points per game. Meanwhile, the team's defense ranks 64th in points allowed (359.5 points allowed per contest).
• The Wildcats are posting 357.5 total yards per game on offense this season (90th-ranked). Meanwhile, they are giving up 339.5 total yards per game (42nd-ranked).
• Northwestern is generating 23.4 points per game on offense this season (101st-ranked). Meanwhile, it is surrendering 21.0 points per contest (34th-ranked) on defense.