Texans vs. Colts Week 3 Dunkel NFL Picks, Predictions and Odds

The Houston Texans (0-2) are small favorites (-2.5) versus the Indianapolis Colts (0-2) in a matchup of two division rivals. The expected point total for the matchup is set at 42.5.

The Texans are putting up 18.5 points per game on offense (21st in NFL), and they rank 24th on the other side of the ball with 28.0 points allowed per game. The Colts' defense has been bottom-five in total defense this season, ceding 514.5 total yards per game, which ranks worst. Offensively, they rank 22nd with 290.0 total yards per contest.

Texans vs. Colts Odds and Game Time

• Date: Sunday, September 27, 2026
• Time: 1 p.m. ET
• City: Indianapolis, Indiana
• Venue: Lucas Oil Stadium
• Total: 42.5 points
• Spread: Texans -2.5
• Moneyline: Texans (-125), Colts (+105)

How to watch Texans vs. Colts

• TV Channel: CBS

Betting the Over/Under: Texans vs. Colts

• Games featuring Houston have hit the over once this season.
• So far this year, two Indianapolis games have gone over the point total.
• The two teams combine to score 45 points per game, 2.5 more points than this matchup's total.
• These two teams surrender 65 points per game combined, 22.5 more points than the total for this matchup.

Betting the Spread: Texans vs. Colts

• Houston has put together a 0-2-0 record against the spread this season.
• Houston has not covered the spread this season (0-1 ATS) when playing as at least 2.5-point favorites.
• The Colts have a record of 1-1-0 against the spread this year.
• Indianapolis has covered the spread once this year (1-1 ATS) when playing as at least 2.5-point underdogs.

Betting the Moneyline: Texans vs. Colts

• Houston has been the moneyline favorite only one other time so far this season, a game they lost.
• The Colts have lost both games they've played as underdogs this season.
• Houston has played as a moneyline favorite of -125 or shorter in only one game this season, which it lost.
• Indianapolis has not won as an underdog of +105 or more on the moneyline this season in two such games.
• The Texans have a 55.6% chance to win this matchup based on the moneyline's implied probability.

Dunkel Prediction for Texans vs. Colts

For more expert NFL picks, visit our Dunkel Index NFL Picks and Predictions.