East Carolina vs. Charleston Southern Dunkel Predictions & Vegas Odds - Nov. 21

The East Carolina Pirates (2-2) host the Charleston Southern Buccaneers (3-3) at Williams Arena at Minges Coliseum, starting at 7 p.m. ET on Friday, November 21, 2025. The Pirates are 9.5-point favorites in the game. The over/under is set at 157.5 for the matchup.

East Carolina dropped its last outing 85-60 against UNC Wilmington on Tuesday. In East Carolina's loss, Joran Riley led the way with a team-high 19 points (adding three rebounds and one assist). Charleston Southern's last outing on Tuesday ended in a 103-91 win against IU Indianapolis. In Charleston Southern's win, A'lahn Sumler led the way with 29 points (adding six rebounds and four assists).

East Carolina vs. Charleston Southern Odds and Game Time

• When: Friday, November 21, 2025 at 7 p.m. ET
• Where: Williams Arena at Minges Coliseum in Greenville, North Carolina
• Spread favorite: East Carolina -9.5
• Moneyline favorite: East Carolina -446
• Moneyline underdog: Charleston Southern +343
• Over/Under: 157.5 points

How to watch East Carolina vs. Charleston Southern

• TV Channel: ESPN+
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: East Carolina vs. Charleston Southern

• East Carolina and its opponent combined to score over 157.5 points, the current matchup's over/under, in 10 of 31 games last year.
• Last season, seven of Charleston Southern's 30 matchups went over 157.5 total points scored.
• The Pirates and the Buccaneers combined to average 9.6 fewer points per game a season ago than the total of 157.5 set for this game.
• The Pirates and the Buccaneers saw their opponents average a combined 5.5 fewer points per game last season than the point total of 157.5 set for this matchup.
• The average point total for East Carolina's games last year was 7.9 fewer points than the total of 157.5 in this matchup.
• The average point total for Charleston Southern in 2024 was 7.2 points lower than this game's over/under.

Betting the Spread: East Carolina vs. Charleston Southern

• East Carolina put together a 14-17-0 ATS record last year.
• The Pirates were favored by 9.5 points or more five times last season, and covered the spread in one of those contests.
• Charleston Southern compiled a 13-17-0 ATS record last year.
• The Buccaneers were an underdog by 9.5 points or more 11 times last year, and covered the spread in six of those games.
• East Carolina was 7-9 against the spread, and 10-6 overall, at home last year.
• East Carolina had one win ATS (1-3) as a 9.5-point favorite or more at home last season.
• Charleston Southern was 9-8 against the spread, and 3-14 overall, on the road last season.

Betting the Moneyline: East Carolina vs. Charleston Southern

• East Carolina won 14 of the 19 games it was favored on the moneyline last season (73.7%).
• The Pirates finished 4-1 last year (winning 80% of their games) when they played as a moneyline favorite of -446 or shorter.
• East Carolina has an 81.7% chance to win this game based on the moneyline's implied probability.
• Charleston Southern was an underdog 25 times last season and won five, or 20%, of those games.
• The Buccaneers had a record of 1-11 in games where bookmakers had them as underdogs of at least +343 on the moneyline.
• The bookmakers' moneyline implies a 22.6% chance of a victory for Charleston Southern.