Duke vs. St. John's Dunkel Predictions & Vegas Odds - Sweet 16

The top-seeded Duke Blue Devils (34-2) and the No. 5 St. John's Red Storm (30-6) will meet on Friday to compete for a spot in the Elite Eight of the NCAA Tournament. Duke is favored by 6.5 points in the Sweet 16 matchup, which begins at 7:10 p.m. ET on CBS. The point total is 140.5 for the matchup.

Duke is coming off of an 81-58 victory over TCU in its last outing on Saturday. Cameron Boozer put up 19 points, 11 rebounds and four assists for Duke. St. John's last contest on Sunday ended in a 67-65 win against Kansas. Zuby Ejiofor's team-high 18 points paced St. John's in the victory.

Duke vs. St. John's Odds and Game Time

• When: Friday, March 27, 2026 at 7:10 p.m. ET
• Where: Capital One Arena in Washington D.C.
• Spread favorite: Duke -6.5
• Moneyline favorite: Duke -292
• Moneyline underdog: St. John's +230
• Over/Under: 140.5 points

How to watch Duke vs. St. John's

• TV Channel: CBS
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Duke vs. St. John's

• Duke and its opponents have hit the over on this game's total (140.5 points) 19 times this season.
• This season, 27 of St. John's games have finished with a combined score higher than 140.5 points.
• The over/under for the matchup of 140.5 is 22.5 points fewer than the combined points per game averages for the Blue Devils (81.9 points per game) and the Red Storm (81.1 points per game).
• The 132.5 points per game these two teams allow their opponents to score combined this season are eight less than the 140.5-point total in this contest.
• On average, Duke has seen a 145-point over/under in its games this season, 4.5 more points than the over/under in this matchup.
• A difference of 9.9 points separates the average over/under in St. John's games (150.4 points) and this game's over/under (140.5).

Betting the Spread: Duke vs. St. John's

• Duke has 20 wins against the spread in 36 games this year.
• The Blue Devils are 17-16 ATS when favored by 6.5 points or more this season.
• Against the spread, St. John's is 21-15-0 this season.
• Duke is 7-8 against the spread, and 15-0 overall, at home.
• As a 6.5-point favorite or more at home, Duke is 7-8 ATS.
• This year in away games, St. John's is 7-3 against the spread and 9-1 overall.
• This year, as 6.5-point underdogs or more on the road, St. John's is 3-2 ATS.

Betting the Moneyline: Duke vs. St. John's

• Duke has won 30, or 93.8%, of the 32 games it has played as the moneyline favorite this season.
• This season, the Blue Devils have won 28 of their 29 games, or 96.6%, when favored by at least -292 on the moneyline.
• The moneyline for this contest implies a 74.5% chance of a victory for Duke.
• St. John's has won in two of the five contests it has been named as the moneyline underdog this year.
• The Red Storm have yet to play a game this season with longer moneyline odds than +230.
• Sportsbooks have implied with the moneyline set for this matchup that St. John's has a 30.3% chance of pulling out a win.