Duke vs. St. John's Dunkel Predictions & Vegas Odds - Sweet 16

The No. 5 St. John's Red Storm (30-6) are 6.5-point underdogs for their Sweet 16 matchup against the No. 1 Duke Blue Devils (34-2) on Friday at 7:10 p.m. ET as the NCAA Tournament continues live from Capital One Arena and airing on CBS. The matchup has an over/under of 141.5 points.

Duke is coming off of an 81-58 win over TCU in its last outing on Saturday. In the win, Cameron Boozer led Duke with 19 points. In its last matchup on Sunday, St. John's earned a 67-65 victory against Kansas. Zuby Ejiofor put up 18 points, nine rebounds and four assists for St. John's.

Duke vs. St. John's Odds and Game Time

• When: Friday, March 27, 2026 at 7:10 p.m. ET
• Where: Capital One Arena in Washington D.C.
• Spread favorite: Duke -6.5
• Moneyline favorite: Duke -296
• Moneyline underdog: St. John's +233
• Over/Under: 141.5 points

How to watch Duke vs. St. John's

• TV Channel: CBS
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Duke vs. St. John's

• A total of 19 of Duke's games this season have gone over Friday's over/under of 141.5 points.
• In St. John's 36 games this season, 26 finished with more combined points than Friday's point total of 141.5.
• Together, the two teams combine for 163 points per game, 21.5 points more than the over/under of 141.5 for this game.
• These two teams give up a combined 132.5 points per game, 9.0 points less than this contest's over/under.
• On average, Duke has seen a 145.0-point over/under in its games this season, 3.5 more points than the over/under in this contest.
• The over/under for this contest is 8.9 points lower than the average over/under in St. John's games this season (150.4 points).

Betting the Spread: Duke vs. St. John's

• Against the spread, Duke is 20-16-0 this year.
• So far this season, the Blue Devils have been installed as favorites by a 6.5-point margin or more 33 times and are 17-16 ATS in those matchups.
• St. John's is 21-15-0 against the spread this season.
• At home this year, Duke is 7-8 against the spread and 15-0 overall.
• At home, as a 6.5-point favorite or greater, Duke is 7-8 ATS.
• This year away from home, St. John's is 7-3 against the spread and 9-1 overall.
• On the road, as 6.5-point underdogs or more, St. John's is 3-2 ATS.

Betting the Moneyline: Duke vs. St. John's

• Duke has entered the game as moneyline favorites 32 times this season and won 30, or 93.8%, of those games.
• The Blue Devils have a record of 28-1 in games where oddsmakers favor them by at least -296 on the moneyline.
• The sportsbooks' moneyline implies a 74.7% chance of a victory for Duke.
• St. John's has been victorious in two of the five contests it has been chosen as a moneyline underdog in this season.
• The Red Storm have yet to play a game this season with longer moneyline odds than +233.
• Oddsmakers have implied with the moneyline set for this matchup that St. John's has a 30% chance of pulling out a win.