Duke vs. Niagara Dunkel Predictions & Vegas Odds - Nov. 21

The No. 5 Duke Blue Devils (5-0) host the Niagara Purple Eagles (2-2) at Cameron Indoor Stadium, beginning at 7 p.m. ET on Friday, November 21, 2025. The Purple Eagles are 39.5-point underdogs in the game. The matchup's point total is set at 146.5.

In its most recent game on Tuesday, Duke claimed a 78-66 victory over Kansas. Cameron Boozer's team-high 18 points led Duke in the win. Niagara's last contest was a 74-68 loss to Le Moyne on Monday. Vice Zanki scored 16 points in Niagara's loss, leading the team.

Duke vs. Niagara Odds and Game Time

• When: Friday, November 21, 2025 at 7 p.m. ET
• Where: Cameron Indoor Stadium in Durham, North Carolina
• Spread favorite: Duke -39.5
• Over/Under: 146.5 points

How to watch Duke vs. Niagara

• TV Channel: ACC Network
• Live Stream: Fubo
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Duke vs. Niagara

• Duke's games finished over 146.5 points scored, its current matchup's point total, 21 times (out of 39) last season.
• Last season, 10 of Niagara's 30 games had a combined total higher than 146.5 points scored.
• These teams averaged a combined 151.7 points per game a season ago, 5.2 more points than the over/under of 146.5 set for this game.
• Opponents of these teams averaged a combined 134.2 points per game last season, 12.3 fewer than the over/under in this matchup.
• The average point total for Duke's games last year was 0.5 fewer points than the total of 146.5 in this matchup.
• The average total for Niagara's games in 2024 was 6.6 fewer points than the point total of 146.5 in this game.

Betting the Spread: Duke vs. Niagara

• Duke put together a 25-14-0 record against the spread last season.
• Niagara compiled a 13-17-0 ATS record last year.
• Duke was 17-0 overall, and 11-6 against the spread, at home last season.
• Last season in away games, Niagara was 7-9 against the spread and 3-13 overall.