Cowboys vs. Chargers Week 16 Dunkel NFL Picks, Predictions and Odds

Having won two straight, the Los Angeles Chargers (10-4) will face the Dallas Cowboys (6-7-1). Despite that, the Cowboys are small favorites (-1.5). An over/under of 50.5 points has been set for the matchup.

While the Cowboys rank second-worst in the NFL in scoring defense with 30 points allowed per game, it's been a different situation offensively, as they rank fifth-best in the NFL (29.1 points per game). The Chargers' defensive unit has been paving the way for the team, as they rank second-best in the NFL with 279.1 total yards surrendered per contest. In terms of offense, they are putting up 337.9 total yards per game, which ranks 15th.

Cowboys vs. Chargers Odds and Game Time

• Date: Sunday, December 21, 2025
• Time: 1 p.m. ET
• City: Arlington, Texas
• Venue: AT&T Stadium
• Total: 50.5 points
• Spread: Cowboys -1.5
• Moneyline: Cowboys (-122), Chargers (+102)

How to watch Cowboys vs. Chargers

• TV Channel: FOX (WDBD-Jackson, MS)
• Live Stream: Fubo

Betting the Over/Under: Cowboys vs. Chargers

• In nine of 14 games this season, the Cowboys and their opponents have combined to score more than 50.5 points.
• Dallas games have hit the over 10 out of 14 times this season.
• The Chargers and their opponents have scored more than 50.5 combined points just twice this season.
• Los Angeles and its opponent have combined to go over the point total six out of 14 times this year.
• These teams score a combined 51.6 points per game, 1.1 more points than this matchup's total.
• Opponents of these teams combine to average 50.3 points per game, 0.2 fewer points than this matchup's total.

Betting the Spread: Cowboys vs. Chargers

• Dallas has compiled a 7-7-0 record against the spread this season.
• Dallas has covered the spread twice this season (2-5 ATS) when playing as at least 1.5-point favorites.
• The Chargers have compiled an 8-6-0 ATS record so far this season.
• Los Angeles has been an underdog by 1.5 points or more three times this year, and covered the spread in three of those matchups.
• The Cowboys are 4-2-1 overall, and 4-3 against the spread, at home.
• At home, as 1.5-point favorites or greater, Dallas has one win ATS (1-3).
• The Chargers have two wins against the spread and are 4-2 overall, on the road.
• Away from home, Los Angeles is unbeaten ATS (1-0) as 1.5-point underdogs or more.

Betting the Moneyline: Cowboys vs. Chargers

• Dallas has been the moneyline favorite seven total times this season. They've finished 3-4 in those games.
• The Chargers have been listed as the underdog three times this season, yet they have won all of those games.
• Dallas has a 3-4 record (winning 42.9% of its games) when it has played as a moneyline favorite of -122 or shorter.
• Los Angeles has been at least a +102 moneyline underdog two times this season and won each of those games.
• The Cowboys have a 55.0% chance to win this game based on the moneyline's implied probability.

Dunkel Prediction for Cowboys vs. Chargers

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