Guardians vs. White Sox Dunkel MLB Picks, Predictions and Prop Bets - Sept. 14

The Cleveland Guardians and Chicago White Sox clash in the first of a three-game series on Monday at Progressive Field, at 6:40 p.m. ET. Gavin Williams (13-7, 3.78 ERA) will start for the Guardians, who are 76-74 this season and second in the AL Central. Sean Newcomb (2-4, 2.77 ERA) is expected to start for the White Sox, who are 76-73 and first in the AL Central.

At home, the Guardians are favored to win on the moneyline (-156) over the White Sox (+126). The total in this contest is set at 7.

Guardians vs. White Sox Odds, Game Time

• Game day: Monday, September 14, 2026
• Game time: 6:40 p.m. ET
• Location: Cleveland, Ohio
• Stadium: Progressive Field
• Favorite: Guardians (-156)
• Underdog: White Sox (+126)
• Over/under: 7

How to Watch Guardians vs. White Sox

• TV Channel: CLEG and CHSN
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Guardians vs. White Sox: Betting the Moneyline

• The Guardians have won 52.2% of the games this season when they were favored on the moneyline (48-44).
• Chicago has won in 52, or 49.5%, of the 105 contests it has been named as odds-on underdogs in this year.
• Cleveland has a record of 14-8 in games when sportsbooks favor them by at least -156 on the moneyline.
• This year, the White Sox have won 15 of 37 games when listed as at least +126 or worse on the moneyline.
• Based on this contest's moneyline, the Guardians' implied win probability is 60.9%.
• The White Sox have an implied victory probability of 44.2% according to the moneyline set for this matchup.

Guardians vs. White Sox: Betting the Spread & Total

• The Guardians have played in 150 games with a set over/under, and have combined with their opponents to go over the total 71 times (71-78-1).
• Games involving Chicago have gone over the total set by sportsbooks in 84 of 149 chances this season.
• The Guardians have put together a 71-79-0 record ATS this season.
• In 149 games with a line this season, the White Sox have a mark of 84-65-0 against the spread.