Clemson vs. West Virginia Dunkel Predictions & Vegas Odds - Nov. 21

The Clemson Tigers (4-1) host the West Virginia Mountaineers (5-0) at TD Arena, beginning at 6:30 p.m. ET on Friday, November 21, 2025. The Mountaineers are 3.5-point underdogs in the game. The matchup has an over/under set at 134.5 points.

Clemson is coming off of an 81-61 win against North Alabama in its last outing on Monday. In Clemson's win, RJ Godfrey led the way with a team-high 16 points (adding six rebounds and three assists). West Virginia heads into this matchup following an 81-59 victory over Lafayette on Monday. DJ Thomas scored 25 points in West Virginia's win, leading the team.

Clemson vs. West Virginia Odds and Game Time

• When: Friday, November 21, 2025 at 6:30 p.m. ET
• Where: TD Arena in Charleston, South Carolina
• Spread favorite: Clemson -3.5
• Moneyline favorite: Clemson -174
• Moneyline underdog: West Virginia +146
• Over/Under: 134.5 points

How to watch Clemson vs. West Virginia

• TV Channel: ESPN U
• Live Stream: Fubo
• Check out the rest of our Dunkel Index NCAA Basketball Picks!

Betting the Over/Under: Clemson vs. West Virginia

• Clemson and its opponents have combined to go over Friday's total of 134.5 points four times this season.
• This season, two West Virginia games have ended with more combined points than Friday's over/under of 134.5.
• The point total for the contest of 134.5 is 22.9 points fewer than the combined points per game averages for the Tigers (84.6 points per game) and the Mountaineers (72.8 points per game).
• This matchup's total is 21.1 fewer points than the 113.4 these two teams combine to allow per game in 2024.
• Clemson has a 143.2 average over/under in its games this season, 8.7 more points than the over/under in this contest.
• A difference of 6.9 points separates this matchup's over/under (134.5 points) and the average over/under in West Virginia's games (127.6) this season.

Betting the Spread: Clemson vs. West Virginia

• Clemson has covered the spread two times this season.
• The Tigers have covered the spread twice this season when favored by 3.5 points or more (in four chances).
• West Virginia has two wins against the spread in five games this season.
• Clemson has covered the spread twice at home, and is 4-0 overall there, this year.
• Clemson has two wins ATS (2-2) as a 3.5-point favorite or greater at home.

Betting the Moneyline: Clemson vs. West Virginia

• Clemson has been the moneyline favorite in five games this season and won four (80%) of those contests.
• The Tigers have entered four games this season favored by -174 or more, and won each of those games.
• The moneyline for this contest implies a 63.5% chance of a victory for Clemson.
• West Virginia will be posted as the moneyline underdog for the first time this season.
• The Mountaineers have yet to play a game this season with longer moneyline odds than +146.
• Bookmakers have implied with the moneyline set for this matchup that West Virginia has a 40.7% chance of pulling out a win.