Clemson vs. Penn State Dunkel NCAA Football Picks, Predictions and Odds - Pinstripe Bowl

The Pinstripe Bowl features a battle between the Clemson Tigers (who are 3-point favorites) and the Penn State Nittany Lions on December 27, 2025 at 12 p.m. ET on ABC.

The Tigers beat the South Carolina Gamecocks, 28-14, in their most recent game.

Facing the Rutgers Scarlet Knights in their most recent game, the Nittany Lions won 40-36.

Clemson vs. Penn State Predictions

For the upcoming contest between the Clemson Tigers and Penn State Nittany Lions, computer-calculated against-the-spread, over/under, and score predictions are below, based on data from Dunkel Index.

• Pick ATS: Nittany Lions (+ 3)
• Pick OU: Over (48.5)
  
• Prediction: Nittany Lions 27 - Tigers 26

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Clemson vs. Penn State Moneylines

Take a look below at the latest moneylines for the Tigers-Nittany Lions matchup.

• Clemson Moneyline: -162
• Penn State Moneyline: +137

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Clemson Betting Insights

• Clemson has won 44.4% of the games this season when it was favored on the moneyline (4-5).
• Clemson is 3-4 (winning 42.9% of its games) when it have played as a moneyline favorite of -162 or shorter.
• In five games this season, the Tigers and their opponents have gone over 48.5 combined points.
• Tigers matchups this year have an average total of 52.6, 4.1 more points than this game's over/under.
• The Tigers score the 65th-most points in college football this season, while the Nittany Lions' offense racks up the 44th-most.

Penn State Betting Insights

• Penn State has been the underdog in three games this season, and it has failed to win any of those contests.
• This season, Penn State has been at least a +137 underdog on the moneyline two times, losing each of those contests.
• Penn State has combined with its opponent to score more than 48.5 points in eight of 12 games this season.
• The average over/under for Penn State's contests this season is 49.9, 1.4 more points than this game's total.

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Key Stats for Clemson vs. Penn State

• The Tigers rank 49th in total offense (405.3 yards per game) and 54th in total defense (353.6 yards allowed per game) this season.
• Clemson ranks 60th in scoring offense (28.7 points per game) and 29th in scoring defense (20.4 points allowed per game) this year.
• In terms of total offense, the Nittany Lions rank 89th in the FBS (359.1 total yards per game) and 33rd on defense (334.3 total yards allowed per game).
• With 31.8 points per game on the offensive side of the ball, Penn State ranks 35th in the FBS. Defensively, it ranks 38th, allowing 21.4 points per game.