White Sox vs. Royals Dunkel MLB Picks, Predictions and Prop Bets - Sept. 22

The Kansas City Royals hope to break their four-game losing run against the Chicago White Sox, at 7:40 p.m. ET on Tuesday. Anthony Kay (9-9, 4.47 ERA) will start for the White Sox, who are 80-76 this season and second in the AL Central. Daniel Lynch (6-5, 3.29 ERA) is expected to start for the Royals, who are 67-89 and fifth in the AL Central.

Sportsbooks have set the White Sox as the moderate moneyline favorites (-121) on the road versus the Royals (+100). The game's total is set at 8.

White Sox vs. Royals Odds, Game Time

• Game day: Tuesday, September 22, 2026
• Game time: 7:40 p.m. ET
• Location: Kansas City, Missouri
• Stadium: Kauffman Stadium
• Favorite: White Sox (-121)
• Underdog: Royals (+100)
• Over/under: 8

How to Watch White Sox vs. Royals

• TV Channel: ROYL and CHSN
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

White Sox vs. Royals: Betting the Moneyline

• The White Sox have won 55.3% of the games this season when they were the moneyline favorite (26-21).
• Kansas City has been underdogs in 102 games this season and has come away with the win 40 times (39.2%) in those contests.
• This season Chicago has won 15 of its 27 games, or 55.6%, when favored by at least -121 on the moneyline.
• This season, the Royals have come away with a win 30 times in 80 chances when named as an underdog of at least +100 or worse on the moneyline.
• The White Sox have an implied moneyline win probability of 54.8% in this game.
• The moneyline set for this matchup implies the Royals have a 50% chance of coming away with a victory in the contest.

White Sox vs. Royals: Betting the Spread & Total

• In the 156 games in which oddsmakers have set an over/under for the White Sox, they have combined with opponents to go over the total 89 times (89-66-1).
• So far this season, Kansas City and its opponents have hit the over in 68 of its 156 games with a total.
• The White Sox have collected an 89-67-0 record against the spread this season (covering 57.1% of the time).
• The Royals are 75-81-0 against the spread in their 156 games that had a posted line this season.