Cubs vs. Marlins Dunkel MLB Picks, Predictions and Prop Bets - Sept. 22

The Miami Marlins hope to end their three-game losing run versus the Chicago Cubs, at 7:40 p.m. ET on Tuesday. Shota Imanaga (11-10, 3.80 ERA) gets the start for the Cubs, who are 87-69 this season and second in the NL Central. Janson Junk (6-9, 4.50 ERA) is starting for the Marlins, who are 76-80 and third in the NL East.

Sportsbooks have made the Cubs a decent moneyline favorite (-208) at home over the Marlins (+168). The game has an over/under set at 6.5 runs.

Cubs vs. Marlins Odds, Game Time

• Game day: Tuesday, September 22, 2026
• Game time: 7:40 p.m. ET
• Location: Chicago, Illinois
• Stadium: Wrigley Field
• Favorite: Cubs (-208)
• Underdog: Marlins (+168)
• Over/under: 6.5

How to Watch Cubs vs. Marlins

• TV Channel: MARQ and MIAM
• Live Stream: Fubo (Watch for free)

Bet now on FanDuel Sportsbook!

Cubs vs. Marlins: Betting the Moneyline

• The Cubs have won 62 of the 109 games they were listed as the moneyline favorite this season (56.9%).
• Miami has come away with 35 wins in the 89 contests it has been listed as the underdogs in this season.
• Chicago is 5-3 this season when entering a game favored by -208 or more on the moneyline.
• This year, the Marlins have won three of seven games when listed as at least +168 or worse on the moneyline.
• Based on this contest's moneyline, the Cubs' implied win probability is 67.5%.
• The moneyline set for this matchup implies the Marlins have a 37.3% chance of coming away with a victory in the contest.

Cubs vs. Marlins: Betting the Spread & Total

• In the 156 games in which oddsmakers have set an over/under for the Cubs, they have combined with opponents to go over the total 87 times (87-64-5).
• So far this season, Miami and its opponents have hit the over in 80 of its 156 games with a total.
• The Cubs are 74-82-0 ATS this season.
• In 156 games with a line this season, the Marlins have a mark of 78-78-0 against the spread.