Bills vs. Chargers Week 3 Dunkel NFL Picks, Predictions and Odds

The Buffalo Bills (2-0) are considered favorites (-7.5) according to the oddsmakers ahead of their game against the Los Angeles Chargers (0-2) on September 27, 2026, starting at 1 p.m. ET, airing on FOX. The matchup has an over/under of 50.5 points.

The Bills have struggled on defense, ranking fifth-worst in the NFL (31.0 points allowed per game) this season. However, they rank best on the other side of the ball, putting up 38.5 points per game. With 289.0 total yards per game on the offensive side of the ball, the Chargers rank 22nd in the NFL in 2026. On defense, they rank 23rd, allowing 349.0 total yards per game.

Bills vs. Chargers Odds and Game Time

• Date: Sunday, September 27, 2026
• Time: 1 p.m. ET
• City: Orchard Park, New York
• Venue: New Highmark Stadium
• Total: 50.5 points
• Spread: Bills -7.5
• Moneyline: Bills (-345), Chargers (+275)

How to watch Bills vs. Chargers

• TV Channel: FOX

Betting the Over/Under: Bills vs. Chargers

• So far this season, two Buffalo games have hit the over.
• Los Angeles has yet to hit the over in any game this season.
• The two teams combine to score 52.5 points per game, 2.0 more points than this matchup's over/under.
• Combined, these teams give up 57 points per game, 6.5 more points than this matchup's over/under.

Betting the Spread: Bills vs. Chargers

• Buffalo has covered twice in two games with a spread this season.
• The Chargers are winless against the spread this year (0-2-0).

Betting the Moneyline: Bills vs. Chargers

• Buffalo has been the moneyline favorite just two other times so far this season, and they won both of the games.
• This is the first time the Chargers will play as underdogs this season.
• Buffalo has yet to play a game with moneyline odds of -345 or shorter.
• Los Angeles has not entered a game this season with longer moneyline odds than +275.
• The Bills have a 77.5% chance to win this contest based on the moneyline's implied probability.

Dunkel Prediction for Bills vs. Chargers

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