Bills vs. Chargers Week 3 Dunkel NFL Picks, Predictions and Odds

The Buffalo Bills (2-0) are favored by 7.5 points against the Los Angeles Chargers (0-2) on September 27, 2026, starting at 1 p.m. ET, airing on FOX. The expected point total for the matchup is 50.5.

While the Bills rank fifth-worst in the NFL in scoring defense with 31.0 points allowed per game, it's been a different story offensively, as they rank best in the NFL (38.5 points per game). From an offensive perspective, the Chargers are posting 289.0 total yards per contest (23rd-ranked). They rank 23rd in the NFL defensively (349.0 total yards allowed per game).

Bills vs. Chargers Odds and Game Time

• Date: Sunday, September 27, 2026
• Time: 1 p.m. ET
• City: Orchard Park, New York
• Venue: New Highmark Stadium
• Total: 50.5 points
• Spread: Bills -7.5
• Moneyline: Bills (-340), Chargers (+270)

How to watch Bills vs. Chargers

• TV Channel: FOX

Betting the Over/Under: Bills vs. Chargers

• This season, games featuring the Bills have gone over the point total twice.
• So far this year, no Los Angeles game has hit the over.
• The teams combine to score 52.5 points per game, 2.0 more points than this matchup's point total.
• These two teams give up 57 points per game combined, 6.5 more points than the total for this contest.

Betting the Spread: Bills vs. Chargers

• Buffalo has put together a perfect 2-0-0 record against the spread this season.
• The Chargers have not won against the spread this year in two games with a spread.

Betting the Moneyline: Bills vs. Chargers

• Buffalo has been the moneyline favorite only two other times so far this season, and they won both of the games.
• This is the first time the Chargers will play as underdogs this season.
• Buffalo has yet to play as a moneyline favorite of -340 or shorter.
• Los Angeles has not entered a game this season with longer moneyline odds than +270.
• The Bills have a 77.3% chance to win this matchup based on the moneyline's implied probability.

Dunkel Prediction for Bills vs. Chargers

For more expert NFL picks, visit our Dunkel Index NFL Picks and Predictions.